{"id":"W2986940115","doi":"10.1182/blood-2019-128773","title":"A Phase 1b/2 Study of TAK-981, a First-in-Class Sumoylation Inhibitor, in Combination with Rituximab in Patients with Relapsed/Refractory (r/r) CD20-Positive Non-Hodgkin Lymphoma (NHL)","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"Antibody-dependent cell-mediated cytotoxicity; Cancer research; Innate immune system; Degranulation; Immune system; Immunology; In vivo; Antibody; Monoclonal antibody; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00137082,0.002265025,0.00331096,0.0005952332,0.0005287845,0.001514422,0.001148438,0.001618317,0.00543352],"category_scores_gemma":[0.0007176535,0.001033456,0.001890131,0.0004756976,0.001081153,0.001479481,0.0004554583,0.004147719,0.001711066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001240284,"about_ca_system_score_gemma":0.001429779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009225634,"about_ca_topic_score_gemma":0.002124054,"domain_scores_codex":[0.999585,0.0001286858,0.00001743324,0.0001131909,0.00003961725,0.0001162126],"domain_scores_gemma":[0.9995455,0.00004622095,0.00006573633,0.00004743172,0.00004663316,0.0002483891],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6202759,0.1810616,0.003347845,0.002534717,0.002842526,0.0005457888,0.0006664703,0.002974272,0.06060802,0.0006236109,0.006821782,0.1176975],"study_design_scores_gemma":[0.511186,0.4734149,0.003823621,0.00005961261,0.0008273629,0.0003811173,0.0001110427,0.0009670967,0.003791101,0.000426434,0.004966475,0.00004533782],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9730712,0.008555454,0.002129985,0.001045001,0.0005988374,0.008910215,0.002121115,0.0002345424,0.0033337],"genre_scores_gemma":[0.9669039,0.006737937,0.00383329,0.002272237,0.0004498435,0.009857392,0.003409036,0.00009587088,0.006440427],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00543352,"threshold_uncertainty_score":0.01817697,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004415805888835392,"score_gpt":0.2108316835450981,"score_spread":0.2064158776562627,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}