{"id":"W2986955991","doi":"10.1093/neuonc/noz175.1137","title":"TMOD-38. PRODUCTION OF D-2-HYDROXYGLUTARATE IN SACCHAROMYCES CEREVISIAE LEADS TO GROWTH IMPAIRMENT AND DECREASED SURVIVAL","year":2019,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; Montreal Neurological Institute and Hospital; McGill University","funders":"","keywords":"Saccharomyces cerevisiae; Biology; Mitochondrion; Carcinogenesis; Respiratory chain; Genetics; Knockout mouse; Biochemistry; Gene; Cell biology; Molecular biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001849684,0.0008764167,0.0005764741,0.0004348444,0.0002233569,0.0005258687,0.0005432128,0.0003519471,0.002288869],"category_scores_gemma":[0.0002069388,0.0002479616,0.0005038615,0.0005756774,0.0002018521,0.0001566976,0.0005468099,0.0006494224,0.001509605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004708771,"about_ca_system_score_gemma":0.0002646516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002448162,"about_ca_topic_score_gemma":0.002066586,"domain_scores_codex":[0.999634,0.00004152313,0.0000671664,0.00008940463,0.0001152447,0.00005255502],"domain_scores_gemma":[0.9997838,0.00003891979,0.00005384917,0.00004099005,0.00002388148,0.00005857823],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001234318,0.00004250027,0.0001675619,0.00005831762,0.00000922199,0.00007348657,0.0000129879,0.00008593695,0.9980403,0.00004459393,0.0001231684,0.001218498],"study_design_scores_gemma":[0.00002074277,0.0001910125,0.003254283,0.00001732317,0.00002261372,0.0001989687,0.00004593145,0.001511735,0.9893956,0.00004463077,0.005280661,0.00001646706],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9516817,0.003081313,0.01157714,0.0004265891,0.0002384659,0.0002331208,0.02714942,0.001485096,0.004127042],"genre_scores_gemma":[0.9476025,0.001336979,0.0127488,0.0001553465,0.00001567908,0.0001986264,0.02886367,0.0004791901,0.008599291],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002448162,"threshold_uncertainty_score":0.007657051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009316071521989282,"score_gpt":0.2594382541529083,"score_spread":0.250122182630919,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}