{"id":"W2986991266","doi":"10.1073/pnas.2003339117","title":"Immune signatures of prodromal multiple sclerosis in monozygotic twins","year":2020,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Deutsche Forschungsgemeinschaft; University College London; National Institute for Health and Care Research; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research","keywords":"Multiple sclerosis; Subclinical infection; Immune system; Disease; Immunology; Monozygotic twin; Autoimmune disease; Population; Biology; Medicine; Genetics; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005916545,0.0003311416,0.0004078786,0.001523925,0.0007237683,0.0004836264,0.0003306126,0.0003895155,0.001287367],"category_scores_gemma":[0.003109486,0.0003273405,0.0002901888,0.0006192833,0.0004383292,0.0001672467,0.0006955091,0.0004798789,0.0001333223],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002972182,"about_ca_system_score_gemma":0.0002243599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002909159,"about_ca_topic_score_gemma":0.002896358,"domain_scores_codex":[0.9995396,0.000132117,0.00005570824,0.0001052772,0.000105165,0.00006209798],"domain_scores_gemma":[0.9991096,0.000139213,0.0003137854,0.0001225836,0.0001353405,0.0001794674],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002355956,0.000195356,0.9282299,0.00006640988,0.00020497,0.005442025,0.00239392,0.0001818462,0.05311253,0.0009020152,0.0003822623,0.006532675],"study_design_scores_gemma":[0.00002574676,0.0002715869,0.9871525,0.00001902039,0.00009827037,0.008570367,0.0006238245,0.0003147154,0.002170928,0.0003805797,0.0003605719,0.0000118325],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995064,0.00009769245,0.00008748514,0.00002147406,0.000006423636,0.000006031703,0.00005163499,0.000001408335,0.0002214327],"genre_scores_gemma":[0.9994187,0.00008938606,0.0001802223,0.00001924499,0.000005147503,0.00000795879,0.00009448904,0.000003497831,0.0001813855],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002909159,"threshold_uncertainty_score":0.005784512,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1382865365524707,"score_gpt":0.3359914071431401,"score_spread":0.1977048705906694,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}