{"id":"W2987070767","doi":"10.1002/mds.27911","title":"Association Between Toll‐Like Receptor 4 (<i>TLR4</i>) and Triggering Receptor Expressed on Myeloid Cells 2 (<i>TREM2</i>) Genetic Variants and Clinical Progression of Huntington's Disease","year":2019,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"European Research Council; Fonds de Recherche du Québec - Santé; Seventh Framework Programme; Medical Research Council Canada; Association for Library Collections and Technical Services; Cure Parkinson’s Trust; University of Cambridge; Evelyn Trust; Alexander S. Onassis Public Benefit Foundation; European Huntington's Disease Network; Parkinson's UK; National Institute for Health and Care Research; NIHR Oxford Biomedical Research Centre; Wellcome Trust; NIHR Cambridge Biomedical Research Centre; Rosetrees Trust; Medical Research Council; Alborada Trust; WILEY","keywords":"TREM2; Disease; TLR4; Microglia; Single-nucleotide polymorphism; Inflammation; Biology; Myeloid; Receptor; Immunology; Medicine; Internal medicine; Gene; Genotype; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000410461,0.0002364626,0.0003073151,0.000127396,0.0001563992,0.00009830842,0.0001659948,0.00009640662,0.0001684075],"category_scores_gemma":[0.0003117912,0.0002279976,0.00008275243,0.0001751551,0.00005342797,0.0002093717,0.0001223304,0.0001827593,0.00005036966],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003776625,"about_ca_system_score_gemma":0.00003738401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003882012,"about_ca_topic_score_gemma":0.000003025941,"domain_scores_codex":[0.997367,0.0003724321,0.0006201503,0.0007369579,0.0006019384,0.0003015804],"domain_scores_gemma":[0.9985164,0.0004380302,0.0004892655,0.0003142703,0.00003638678,0.0002055832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001452403,0.000193618,0.05139288,0.00007321582,0.00001369081,5.072378e-7,0.00008701757,0.00005230014,0.9360811,0.0001605344,0.001098703,0.01070126],"study_design_scores_gemma":[0.002695679,0.0006406618,0.05117834,0.0001074425,0.00005289907,2.452507e-8,0.0000410085,0.001068666,0.9387792,0.0008284277,0.004216183,0.0003914878],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963934,0.00001723181,0.0001721022,0.001325208,0.0007466874,0.0009967771,0.00006255296,0.00008050151,0.0002054959],"genre_scores_gemma":[0.9944131,0.001014811,0.0005743181,0.00238541,0.00009609073,0.00003693737,0.00001491001,0.00004787013,0.001416562],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01030977,"threshold_uncertainty_score":0.9297472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01497188515283524,"score_gpt":0.2612504497280863,"score_spread":0.2462785645752511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}