{"id":"W2987070767","doi":"10.1002/mds.27911","title":"Association Between Toll‐Like Receptor 4 (<i>TLR4</i>) and Triggering Receptor Expressed on Myeloid Cells 2 (<i>TREM2</i>) Genetic Variants and Clinical Progression of Huntington's Disease","year":2019,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"European Research Council; Fonds de Recherche du Québec - Santé; Seventh Framework Programme; Medical Research Council Canada; Association for Library Collections and Technical Services; Cure Parkinson’s Trust; University of Cambridge; Evelyn Trust; Alexander S. Onassis Public Benefit Foundation; European Huntington's Disease Network; Parkinson's UK; National Institute for Health and Care Research; NIHR Oxford Biomedical Research Centre; Wellcome Trust; NIHR Cambridge Biomedical Research Centre; Rosetrees Trust; Medical Research Council; Alborada Trust; WILEY","keywords":"TREM2; Disease; TLR4; Microglia; Single-nucleotide polymorphism; Inflammation; Biology; Myeloid; Receptor; Immunology; Medicine; Internal medicine; Gene; Genotype; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003157489,0.0002666998,0.0001968805,0.0005040945,0.0002697444,0.000276946,0.0001937639,0.000411077,0.003126762],"category_scores_gemma":[0.0007734416,0.0001640571,0.0002311469,0.000291623,0.0002568563,0.0001429513,0.0001737937,0.0003398243,0.0001831735],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001161929,"about_ca_system_score_gemma":0.0001181208,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001026127,"about_ca_topic_score_gemma":0.001068869,"domain_scores_codex":[0.9998536,0.00003816964,0.00001938929,0.0000499049,0.00001761893,0.00002118391],"domain_scores_gemma":[0.9993661,0.0001736448,0.0002804681,0.0000354173,0.00004482332,0.00009958287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008491206,0.00005746025,0.9909618,0.00001516265,0.0001334859,0.0007432663,0.000065265,0.00009940976,0.00542526,0.00005454732,0.000182955,0.001412316],"study_design_scores_gemma":[0.00002311433,0.0001572116,0.9969289,0.000005772518,0.00005973685,0.00187872,0.00003785308,0.0002746554,0.0004549039,0.00005158678,0.0001238269,0.000003713826],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995617,0.0001206988,0.00006064706,0.00001745946,0.000003229425,0.000002500278,0.00008350646,0.000002513796,0.0001475931],"genre_scores_gemma":[0.9994978,0.00004688273,0.00009195903,0.00001410423,0.00001135918,0.000004053474,0.0001431806,0.000001728043,0.0001891289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003126762,"threshold_uncertainty_score":0.01046008,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01497188515283524,"score_gpt":0.2612504497280863,"score_spread":0.2462785645752511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}