{"id":"W2987081466","doi":"10.1182/blood-2019-123711","title":"Updated Results from the Venetoclax (Ven) in Combination with Idasanutlin (Idasa) Arm of a Phase 1b Trial in Elderly Patients (Pts) with Relapsed or Refractory (R/R) AML Ineligible for Cytotoxic Chemotherapy","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Alberta; McGill University; Jewish General Hospital","funders":"","keywords":"Ven; Medicine; Tolerability; Internal medicine; Venetoclax; Gastroenterology; Oncology; Mucositis; Surgery; Adverse effect; Chemotherapy; Leukemia; Chronic lymphocytic leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006736925,0.0002407455,0.0005735537,0.0002660969,0.00004576964,0.00001773934,0.0002594073,0.0001971846,0.00004850377],"category_scores_gemma":[0.0004480041,0.0001425358,0.00005640859,0.0007683626,0.00008773117,0.0001496256,0.00003877334,0.0004797484,0.000009562887],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003836601,"about_ca_system_score_gemma":0.0009702155,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007577601,"about_ca_topic_score_gemma":0.0004385572,"domain_scores_codex":[0.9977093,0.0001623023,0.0006715102,0.0004825791,0.000591735,0.0003825963],"domain_scores_gemma":[0.9980344,0.0005558521,0.0003536457,0.0006511439,0.0003156922,0.00008924124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9265573,0.0211734,0.02324148,0.0001259411,0.000365268,0.00006193094,0.003396518,0.0000364669,0.01950492,0.00002037597,0.001393673,0.004122698],"study_design_scores_gemma":[0.9163699,0.03755165,0.01458673,0.0005873891,0.0001043438,0.0000037112,0.0002726426,0.0008807507,0.02820424,0.00006220451,0.001145392,0.000231059],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930764,0.0000328527,0.00002483067,0.0004315755,0.0000619305,0.006045226,0.0001515648,0.00003208594,0.0001435327],"genre_scores_gemma":[0.9974674,0.00003498589,0.0007437068,0.0002045344,0.00009350329,0.0002727544,0.0008071869,0.0000638417,0.0003121099],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01637825,"threshold_uncertainty_score":0.5812443,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01984738884418036,"score_gpt":0.2982298608886551,"score_spread":0.2783824720444747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}