{"id":"W2987081466","doi":"10.1182/blood-2019-123711","title":"Updated Results from the Venetoclax (Ven) in Combination with Idasanutlin (Idasa) Arm of a Phase 1b Trial in Elderly Patients (Pts) with Relapsed or Refractory (R/R) AML Ineligible for Cytotoxic Chemotherapy","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Alberta; McGill University; Jewish General Hospital","funders":"","keywords":"Ven; Medicine; Tolerability; Internal medicine; Venetoclax; Gastroenterology; Oncology; Mucositis; Surgery; Adverse effect; Chemotherapy; Leukemia; Chronic lymphocytic leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002243721,0.0004704327,0.001030249,0.0003106025,0.0001497931,0.0008348389,0.000489909,0.000464873,0.002174556],"category_scores_gemma":[0.001311652,0.0002163699,0.0006608866,0.0004598571,0.000238053,0.0004440135,0.0002512519,0.001229087,0.0003547744],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005261485,"about_ca_system_score_gemma":0.0006023176,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006205468,"about_ca_topic_score_gemma":0.0021109,"domain_scores_codex":[0.9993982,0.0003569624,0.00004580118,0.00006128227,0.00006935011,0.00006842628],"domain_scores_gemma":[0.9989501,0.0002952993,0.0003926762,0.00006840709,0.00007901064,0.0002146949],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5799173,0.007388108,0.03507462,0.002288935,0.004379672,0.0004509946,0.0004007558,0.005965088,0.0507399,0.0004903233,0.02127899,0.2916253],"study_design_scores_gemma":[0.3968446,0.3076242,0.224163,0.0004449645,0.008152133,0.002386024,0.0001874835,0.003666109,0.01517931,0.000855015,0.04037742,0.0001197405],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.970727,0.01377179,0.0009454488,0.0008456121,0.0001165116,0.001071198,0.007513843,0.0001291059,0.004879397],"genre_scores_gemma":[0.97227,0.005832308,0.002320428,0.00106295,0.0002114613,0.0009099084,0.01525247,0.00004236363,0.002098327],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002243721,"threshold_uncertainty_score":0.01186609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01984738884418036,"score_gpt":0.2982298608886551,"score_spread":0.2783824720444747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}