{"id":"W2987125675","doi":"10.1101/837138","title":"Beyond Conventional Models: Recreating the Initiation, Evolution, and Genome of GBM","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Canada's Michael Smith Genome Sciences Centre; Hotchkiss Brain Institute; University of British Columbia; University of Calgary","funders":"","keywords":"Biology; Platelet-derived growth factor receptor; Subventricular zone; Growth factor; Genome instability; Cell biology; Multinucleate; Cancer research; Neural stem cell; Stem cell; Genetics; Receptor; DNA damage","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002135446,0.0002495407,0.0002018334,0.000349619,0.000281039,0.0006541656,0.000412917,0.000487067,0.001376165],"category_scores_gemma":[0.0001922621,0.0001516854,0.000297523,0.0001809206,0.0005306564,0.0006206148,0.0006057748,0.001524213,0.0002934889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004182712,"about_ca_system_score_gemma":0.0003806556,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000846017,"about_ca_topic_score_gemma":0.001828966,"domain_scores_codex":[0.9999001,0.00002555905,0.000006707439,0.00001794679,0.00003213678,0.00001757434],"domain_scores_gemma":[0.999887,0.0000246892,0.00001936931,0.00002823459,0.00001069043,0.0000300859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001463577,0.0001399555,0.001584883,0.0001621842,0.00002449519,0.0002917935,0.0002375474,0.002034374,0.9653931,0.01687096,0.000864994,0.0122493],"study_design_scores_gemma":[0.00008839294,0.002772448,0.01229759,0.00019854,0.0001795141,0.002608332,0.000878834,0.0217494,0.7945225,0.02683103,0.1377962,0.00007714771],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8928794,0.004978392,0.08711832,0.002198393,0.0004363995,0.0001388742,0.0009006978,0.0006316538,0.01071796],"genre_scores_gemma":[0.9554561,0.004590218,0.03199387,0.0005368777,0.00005329875,0.0001386267,0.000712416,0.0001401955,0.006378381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001376165,"threshold_uncertainty_score":0.004603684,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02049549483952078,"score_gpt":0.2311867947417292,"score_spread":0.2106912999022085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}