{"id":"W2987201345","doi":"10.1016/j.celrep.2019.10.017","title":"Anti-CRISPR AcrIIA5 Potently Inhibits All Cas9 Homologs Used for Genome Editing","year":2019,"lang":"en","type":"article","venue":"Cell Reports","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health","keywords":"CRISPR; Genome editing; Cas9; Genome; Computational biology; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002920478,0.0005819427,0.0004543807,0.000317121,0.0001996596,0.0004349735,0.0004017205,0.0002963812,0.001106403],"category_scores_gemma":[0.0001409696,0.0001747017,0.0003490053,0.0001833068,0.0001971134,0.0001854297,0.0002962984,0.0005361277,0.0005999875],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003040765,"about_ca_system_score_gemma":0.0002110715,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000545961,"about_ca_topic_score_gemma":0.001038047,"domain_scores_codex":[0.9994774,0.00006187746,0.00007813962,0.0001098249,0.0002122789,0.00006040518],"domain_scores_gemma":[0.9998019,0.00002804742,0.0000647336,0.00002424768,0.00002679388,0.00005420163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002444583,0.00001733631,0.0001293583,0.00002588683,0.000004506912,0.00001787431,0.000003593522,0.00005112627,0.9980633,0.00004386779,0.00003359405,0.001585105],"study_design_scores_gemma":[0.000002639629,0.0001626349,0.0009000693,0.000002371014,0.000007637015,0.0001556616,0.00000351069,0.0003646944,0.9963839,0.000006697635,0.00200804,0.000002154454],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9535159,0.003744943,0.03289422,0.0001457356,0.0001146691,0.0001483403,0.0008180628,0.0006611147,0.007956847],"genre_scores_gemma":[0.9794319,0.001119351,0.01415315,0.000107252,0.00001336871,0.00004529151,0.001243333,0.00005693709,0.003829552],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001106403,"threshold_uncertainty_score":0.003701329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007064573563153331,"score_gpt":0.2653714653455764,"score_spread":0.2583068917824231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}