{"id":"W2987201345","doi":"10.1016/j.celrep.2019.10.017","title":"Anti-CRISPR AcrIIA5 Potently Inhibits All Cas9 Homologs Used for Genome Editing","year":2019,"lang":"en","type":"article","venue":"Cell Reports","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health","keywords":"CRISPR; Genome editing; Cas9; Genome; Computational biology; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002252689,0.0001881287,0.0002065199,0.00004197538,0.00004755241,0.00002722894,0.00009964051,0.0001699237,0.00002892373],"category_scores_gemma":[0.00004888081,0.0001925539,0.0001428952,0.00004788689,0.0000208496,0.000003788129,0.0001027632,0.00008462739,0.00001539294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001345942,"about_ca_system_score_gemma":0.00004594246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001076932,"about_ca_topic_score_gemma":0.000004984915,"domain_scores_codex":[0.9986575,0.00001145434,0.0003266363,0.0004952588,0.0001191161,0.0003900777],"domain_scores_gemma":[0.9991851,0.00001080111,0.0001337248,0.0004872812,0.0000806071,0.000102503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000005540957,0.00003110597,0.003494209,0.00007682697,0.00002733725,0.00006652687,0.00005497922,0.001124584,0.9937243,0.000002081193,0.001221354,0.0001711158],"study_design_scores_gemma":[0.0003325439,0.0001493664,0.001555645,0.00001001831,0.00002651157,0.0002603698,0.00006051529,0.00008517486,0.8820709,0.00002270458,0.1151746,0.0002516621],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893268,0.001113838,0.006691263,0.00005175432,0.0009086715,0.0004519439,0.0000110017,0.00002897136,0.001415765],"genre_scores_gemma":[0.9952477,0.00004984902,0.001083647,0.0001435534,0.0004812441,0.00002702914,0.0002621232,0.00004822413,0.002656582],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1139533,"threshold_uncertainty_score":0.785212,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007064573563153331,"score_gpt":0.2653714653455764,"score_spread":0.2583068917824231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}