{"id":"W2987213856","doi":"10.1016/j.celrep.2019.10.007","title":"Natural HIV-1 Nef Polymorphisms Impair SERINC5 Downregulation Activity","year":2019,"lang":"en","type":"article","venue":"Cell Reports","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"AIDS Vancouver; McGill University; Centre Hospitalier de l’Université de Montréal; Université de Montréal; McGill University Health Centre; Simon Fraser University","funders":"Canadian Institutes of Health Research; National Institutes of Health; Michael Smith Health Research BC; Canada Research Chairs; AIDS Healthcare Foundation; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation","keywords":"Downregulation and upregulation; Infectivity; Biology; Allele; CTL*; Pathogenesis; Gene; Viral replication; Genetics; Cell biology; Immune system; Immunology; Virus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0001473508,0.0001437482,0.0001868854,0.00006822859,0.00009890689,0.00001540682,0.00006586599,0.0001389159,0.002072711],"category_scores_gemma":[0.00001736695,0.0001145838,0.00009993206,0.00008203821,0.0000595965,0.0001222745,0.00007105831,0.000213728,0.00510566],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008186998,"about_ca_system_score_gemma":0.00009021355,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000121733,"about_ca_topic_score_gemma":0.00001031488,"domain_scores_codex":[0.9989904,0.00007651618,0.0001753397,0.0003329483,0.00005655969,0.0003682359],"domain_scores_gemma":[0.9992998,0.00004405243,0.000125221,0.0004498774,0.00004147474,0.00003956848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001075704,0.0001713174,0.04360091,0.00001446638,0.00006764513,0.000268678,0.00008035253,0.000006729218,0.9466987,0.0000159854,0.004374445,0.004593175],"study_design_scores_gemma":[0.0009869875,0.0002071737,0.4241018,0.00001345045,0.0000227836,0.0008120501,0.00002737998,0.000008801772,0.5229228,0.00008075363,0.050594,0.0002220609],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841765,0.0009350342,0.00001559234,0.0001490767,0.0007346326,0.0003517501,0.00001292873,0.00008378451,0.01354069],"genre_scores_gemma":[0.9429078,0.00001073719,0.00003751267,0.00002120374,0.00002382885,0.00001611772,0.0003503886,0.00001247737,0.05661998],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.423776,"threshold_uncertainty_score":0.9988396,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006377596942843895,"score_gpt":0.2262250782835966,"score_spread":0.2198474813407527,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}