{"id":"W2987213856","doi":"10.1016/j.celrep.2019.10.007","title":"Natural HIV-1 Nef Polymorphisms Impair SERINC5 Downregulation Activity","year":2019,"lang":"en","type":"article","venue":"Cell Reports","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"AIDS Vancouver; McGill University; Centre Hospitalier de l’Université de Montréal; Université de Montréal; McGill University Health Centre; Simon Fraser University","funders":"Canadian Institutes of Health Research; National Institutes of Health; Michael Smith Health Research BC; Canada Research Chairs; AIDS Healthcare Foundation; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation","keywords":"Downregulation and upregulation; Infectivity; Biology; Allele; CTL*; Pathogenesis; Gene; Viral replication; Genetics; Cell biology; Immune system; Immunology; Virus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001555423,0.0002327115,0.0001719095,0.0001144893,0.0001257559,0.0002975661,0.0002232584,0.0002171613,0.001969309],"category_scores_gemma":[0.0002897155,0.00008288828,0.0002226213,0.00007173175,0.0002017018,0.0001285967,0.0001591201,0.0003265643,0.0003330942],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002480299,"about_ca_system_score_gemma":0.0001322962,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000835025,"about_ca_topic_score_gemma":0.0008449946,"domain_scores_codex":[0.9998202,0.00004354065,0.00002266109,0.00002706947,0.00004367819,0.00004298073],"domain_scores_gemma":[0.999803,0.00006660256,0.00004302002,0.00003332817,0.00001697403,0.00003710386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000125476,0.00003927038,0.0007903196,0.00001737796,0.000007620151,0.00006141078,0.00001176521,0.00004401384,0.9977695,0.0001201658,0.00002154589,0.0009914829],"study_design_scores_gemma":[0.00000917281,0.0003070661,0.01005989,0.000004481133,0.00001395249,0.0004826072,0.0000269331,0.0006515507,0.9875085,0.00004347301,0.0008867628,0.00000547791],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972163,0.0004144021,0.0009442042,0.00002084347,0.00001824069,0.00001046049,0.0001846966,0.0000218868,0.001169089],"genre_scores_gemma":[0.9984108,0.0001163097,0.0005717226,0.00001266911,0.00000204453,0.000005281723,0.0002618323,0.000007641304,0.0006117129],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001969309,"threshold_uncertainty_score":0.006587982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006377596942843895,"score_gpt":0.2262250782835966,"score_spread":0.2198474813407527,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}