{"id":"W2987348921","doi":"10.1371/journal.pntd.0007693","title":"The repositioning of epigenetic probes/inhibitors identifies new anti-schistosomal lead compounds and chemotherapeutic targets","year":2019,"lang":"en","type":"article","venue":"PLoS neglected tropical diseases","topic":"Parasites and Host Interactions","field":"Immunology and Microbiology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Regional Development Fund; Biotechnology and Biological Sciences Research Council; Ministero dello Sviluppo Economico; Cardiff University; Ontario Ministry of Economic Development and Innovation; Llywodraeth Cymru; Wellcome Trust; Wellcome; Canadian Institutes of Health Research; Genome Canada; GlaxoSmithKline; Pfizer; Eli Lilly and Company","keywords":"Epigenetics; Chemotherapeutic drugs; Biology; Neglected tropical diseases; Drug repositioning; Schistosomiasis; Lead (geology); Schistosoma; Computational biology; Medicine; Drug; Pathology; Immunology; Pharmacology; Schistosoma mansoni; Cancer; Genetics; Helminths; Public health","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004896375,0.0006452595,0.0006452558,0.0006361458,0.0001889422,0.0006570469,0.0004689246,0.0004527131,0.00342127],"category_scores_gemma":[0.0003735692,0.0003092914,0.000572286,0.0003641171,0.0003253474,0.0003801084,0.0003971309,0.0008763311,0.0009305364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005769757,"about_ca_system_score_gemma":0.0004558457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004766801,"about_ca_topic_score_gemma":0.002093423,"domain_scores_codex":[0.9997577,0.00002823438,0.00001546597,0.00005797111,0.00009394988,0.00004668022],"domain_scores_gemma":[0.9997737,0.00004693152,0.00006530801,0.00002831919,0.00005329126,0.00003249419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002810858,0.0002193219,0.0009358102,0.0004136676,0.00005621915,0.0002370278,0.00004552965,0.003163246,0.960772,0.0006830862,0.0006966216,0.03249645],"study_design_scores_gemma":[0.0001868534,0.002688838,0.002808947,0.00005933016,0.0001789411,0.0007902161,0.00004763191,0.004781079,0.9685528,0.0002478809,0.0196196,0.00003783434],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9269869,0.02475569,0.02900745,0.000913036,0.0001954989,0.0009511753,0.003136449,0.001219002,0.01283474],"genre_scores_gemma":[0.9486648,0.01297392,0.02602761,0.0004582696,0.0000449777,0.0003001564,0.00266855,0.0001062886,0.008755238],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00342127,"threshold_uncertainty_score":0.01144528,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008059022156494447,"score_gpt":0.2334667505812542,"score_spread":0.2254077284247597,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}