{"id":"W2987417079","doi":"10.1182/blood-2019-124392","title":"Combination of Venetoclax and Ibrutinib Increases bcl2-Dependent Apoptotic Priming, Reduces ITK-Phosphorylation and Is Clinically Promising in Relapsed/Refractory T-Prolymphocytic Leukemia","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Venetoclax; Ibrutinib; Prolymphocytic leukemia; Cancer research; Idelalisib; Medicine; Pharmacology; Leukemia; Oncology; Internal medicine; Chronic lymphocytic leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008729472,0.0003067144,0.0002836509,0.0002895581,0.0001260235,0.0002492142,0.0001483577,0.0001343845,0.002103156],"category_scores_gemma":[0.00009624355,0.00008298628,0.000155859,0.0002374407,0.0001093081,0.0001069981,0.0001266935,0.0004214226,0.0002747319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002032137,"about_ca_system_score_gemma":0.0001459402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003756749,"about_ca_topic_score_gemma":0.001010055,"domain_scores_codex":[0.9999127,0.00001380855,0.000007587353,0.00002337165,0.00001998929,0.00002241826],"domain_scores_gemma":[0.9999617,0.000007935277,0.000008346673,0.000004426982,0.000003416574,0.0000141602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008526107,0.0002712563,0.0009219598,0.00008095982,0.00002287345,0.00006753116,0.00001638925,0.0004373484,0.9829167,0.00004905468,0.0003615532,0.01400176],"study_design_scores_gemma":[0.0003220125,0.007275734,0.02036511,0.000014025,0.0001026453,0.001091062,0.00003533674,0.00174765,0.9613148,0.00005654312,0.00766055,0.00001450949],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942065,0.002397644,0.0006583487,0.00007812923,0.00002998851,0.00005924223,0.0006076599,0.0001043634,0.001858019],"genre_scores_gemma":[0.9956387,0.0007547868,0.001631202,0.00003247623,0.00001456135,0.00003561666,0.0006969637,0.00000894693,0.001186787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002103156,"threshold_uncertainty_score":0.007035732,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01600619031098156,"score_gpt":0.2866862771361183,"score_spread":0.2706800868251368,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}