{"id":"W2987417158","doi":"10.1183/13993003.01785-2019","title":"Upregulation of smooth muscle Rho-kinase protein expression in human asthma","year":2019,"lang":"en","type":"letter","venue":"European Respiratory Journal","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; St. Paul's Hospital; University of British Columbia Hospital","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; British Columbia Lung Association","keywords":"ROCK2; Medicine; Downregulation and upregulation; ROCK1; Gene isoform; Rho-associated protein kinase; Asthma; Phenotype; Smooth muscle; Protein kinase A; Kinase; Anatomy; Cell biology; Internal medicine; Gene; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001117658,0.0003344057,0.0003285008,0.0003089716,0.0001252864,0.00006631181,0.0004077369,0.000409261,0.0001396462],"category_scores_gemma":[0.00009527573,0.0003196358,0.0002361583,0.0001164735,0.00008393011,0.00001403611,0.0001678529,0.001126851,0.00002357691],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000490837,"about_ca_system_score_gemma":0.0001494466,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001756778,"about_ca_topic_score_gemma":0.000001520692,"domain_scores_codex":[0.9967065,0.001239651,0.0008014805,0.0004677658,0.0004428775,0.0003417217],"domain_scores_gemma":[0.9983221,0.000009582013,0.0008331505,0.0005916383,0.0001705387,0.00007299293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003953601,0.0000366582,0.0001217612,0.0001116293,0.0000133056,0.0002784542,0.00002554394,0.0002322667,0.9157097,0.000003290632,0.08035231,0.003075501],"study_design_scores_gemma":[0.0009947822,0.0002983596,0.003629399,0.0007349807,0.000007947504,0.00001527051,0.000009209903,0.000008042724,0.217536,0.0000253546,0.7764051,0.0003356345],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848992,0.0031425,0.001426572,0.004120818,0.0003721971,0.001011834,0.00004138954,0.00002697903,0.004958481],"genre_scores_gemma":[0.915505,0.00003429265,0.001220169,0.06850456,0.0106074,0.00002562534,0.0005243142,0.000392647,0.003186015],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6981738,"threshold_uncertainty_score":0.9999256,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01889230296907997,"score_gpt":0.2509105679175709,"score_spread":0.232018264948491,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}