{"id":"W2987573161","doi":"10.1101/820647","title":"Structural basis for the binding selectivity of human CDY chromodomains","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Institute on Drug Abuse; Natural Sciences and Engineering Research Council of Canada; Peking University; Ministry of Education, India; Tsinghua University; Directorate for Biological Sciences; National Institutes of Health; Ontario Ministry of Research, Innovation and Science; Ontario Genomics; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; Biological and Environmental Research; National Natural Science Foundation of China; University of Chicago; Pfizer; Novartis Pharma; Ontario Genomics Institute; Central China Normal University; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Argonne National Laboratory; University of North Carolina at Chapel Hill; U.S. Department of Energy","keywords":"Chromodomain; Histone; Lysine; Heterochromatin protein 1; Histone H3; Structural motif; Epigenetics; Biology; Chemistry; Computational biology; Genetics; Chromatin; Cell biology; Biochemistry; Gene; Amino acid; Heterochromatin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008863531,0.0001664544,0.0001771651,0.00006996111,0.0001595542,0.0001583205,0.0001731627,0.0002406961,0.002974013],"category_scores_gemma":[0.0001343111,0.0001001751,0.000134823,0.0000712953,0.0001734419,0.00008149818,0.0001573056,0.0003165639,0.0004961984],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003662045,"about_ca_system_score_gemma":0.0001744437,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001381263,"about_ca_topic_score_gemma":0.001023238,"domain_scores_codex":[0.999927,0.00001340918,0.0000036183,0.00002438341,0.00001278156,0.00001885856],"domain_scores_gemma":[0.9999392,0.00001759055,0.000009761361,0.000005012729,0.000007085691,0.00002138288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000357175,0.0000266858,0.0005519061,0.00003790763,0.000006946697,0.0001374505,0.00001923654,0.0006297393,0.995954,0.0003288772,0.0001250478,0.001824915],"study_design_scores_gemma":[0.00006096934,0.0001748588,0.003764821,0.000004648796,0.00000944621,0.0002760474,0.00002708431,0.003549329,0.9892208,0.0001106569,0.002792115,0.000009204266],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925038,0.0005355823,0.004682888,0.0001359086,0.0000274577,0.00002883443,0.0003564754,0.00005858525,0.001670477],"genre_scores_gemma":[0.9972954,0.00008017222,0.00169091,0.00005797074,0.000002622648,0.000007512183,0.0001766315,0.000008687814,0.0006800334],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002974013,"threshold_uncertainty_score":0.009949028,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0117715815392752,"score_gpt":0.2287571300379531,"score_spread":0.2169855484986779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}