{"id":"W2987595422","doi":"10.25251/skin.3.supp.14","title":"Influence of baseline demographics/disease characteristics on efficacy of an oral selective TYK2 inhibitor, BMS-986165, in patients with moderate to severe plaque psoriasis: Phase 2, randomized, placebo-controlled trial","year":2019,"lang":"en","type":"article","venue":"SKIN The Journal of Cutaneous Medicine","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; Probity Medical Research","funders":"","keywords":"Medicine; Randomized controlled trial; Demographics; Placebo; Plaque psoriasis; Internal medicine; Psoriasis; Dermatology; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002096412,0.0003224166,0.002082235,0.0006699185,0.00005089112,0.000007911386,0.0002145867,0.00009150759,0.00008994029],"category_scores_gemma":[0.00373163,0.0001709095,0.0002457378,0.0004959204,0.000188828,0.0001210103,0.00002125531,0.0006825945,0.000002567763],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009452246,"about_ca_system_score_gemma":0.000406514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005356215,"about_ca_topic_score_gemma":0.00001624192,"domain_scores_codex":[0.9960362,0.0007452125,0.001776796,0.0002200582,0.0009597239,0.0002619877],"domain_scores_gemma":[0.9942281,0.002181069,0.001516759,0.0003864308,0.001340696,0.0003469885],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9738322,0.002815574,0.0006631829,0.00006868759,0.000510291,0.0001209,0.001183522,0.01734852,0.002668978,0.00001725484,0.0001020385,0.000668865],"study_design_scores_gemma":[0.9623547,0.0256563,0.001185732,0.002806135,0.001499083,0.0002769085,0.0001682951,0.003823697,0.001968688,0.00005079054,0.0000302859,0.0001794377],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949878,0.00005029312,0.0001468437,0.0005750189,0.0003986004,0.003727582,0.00004706293,0.000009256735,0.00005755399],"genre_scores_gemma":[0.9987963,0.00005619907,0.0001384118,0.0004239074,0.0004684674,0.00001863513,0.00002553621,0.00003736577,0.00003515906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02284072,"threshold_uncertainty_score":0.6969486,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007098689643237144,"score_gpt":0.2681841225595791,"score_spread":0.261085432916342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}