{"id":"W2987629825","doi":"10.1002/cbic.201900591","title":"Regulation of Immune Activation by Optical Control of TLR1/2 Heterodimerization","year":2019,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"National Natural Science Foundation of China","keywords":"Chemistry; Immune system; Cell biology; Toll-like receptor; Stimulation; Receptor; Biophysics; Innate immune system; Biochemistry; Immunology; Biology; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001836608,0.00008991675,0.0002290309,0.00006007223,0.00002223624,0.000002735036,0.00008606532,0.000203954,0.0003491898],"category_scores_gemma":[0.00008665827,0.00008719644,0.00007227927,0.0001032769,0.00007719391,0.0001199903,0.00001768314,0.00007791236,0.00009507832],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002019594,"about_ca_system_score_gemma":0.00002556962,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001021487,"about_ca_topic_score_gemma":4.675043e-8,"domain_scores_codex":[0.9992645,0.00005827076,0.0003929949,0.0001281617,0.00004076911,0.0001153335],"domain_scores_gemma":[0.9992768,0.00008122972,0.0002903641,0.0002263764,0.0001191559,0.000006070332],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000417638,0.00006415627,0.0003849201,0.00005601177,0.00006599266,1.234516e-8,0.0001066233,0.00001505542,0.996577,0.0004795952,0.0001931281,0.001639919],"study_design_scores_gemma":[0.001509932,0.0001257169,0.009156409,0.00004288319,0.00001942076,0.000001770087,0.00004470019,0.0000666593,0.9878946,0.00002932648,0.001028689,0.00007989192],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951668,0.0004911548,0.002312255,0.0001075026,0.0001380611,0.0002336313,0.000005702866,0.0000188349,0.001526019],"genre_scores_gemma":[0.9981929,0.00001671265,0.00003366138,0.00001536835,0.000007313847,0.000006032775,0.0004457406,0.000009195499,0.001273044],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008771488,"threshold_uncertainty_score":0.3823383,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003067732844086089,"score_gpt":0.1889640748071233,"score_spread":0.1858963419630372,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}