{"id":"W2987673838","doi":"10.1182/blood-2019-126509","title":"Fostamatinib, a Spleen Tyrosine Kinase (SYK) Inhibitor, for the Treatment of Warm Antibody Autoimmune Hemolytic Anemia (wAIHA): Final Results of the Phase 2, Multicenter, Open-Label Study","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Syk; Medicine; Autoimmune hemolytic anemia; Anemia; Internal medicine; Gastroenterology; Tolerability; Rituximab; Immunology; Pharmacology; Adverse effect; Tyrosine kinase; Antibody; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007272317,0.0003063867,0.0007556872,0.00008943304,0.0001335165,0.00003883588,0.0007113659,0.00009872318,0.00004011566],"category_scores_gemma":[0.0004378674,0.0001642849,0.0001803141,0.0004035941,0.0002082553,0.00008397825,0.0003554185,0.0001608132,0.00001607581],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001170132,"about_ca_system_score_gemma":0.002492028,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001905937,"about_ca_topic_score_gemma":0.00005905853,"domain_scores_codex":[0.9972695,0.0001342666,0.0009180785,0.0004941585,0.0007014648,0.0004825515],"domain_scores_gemma":[0.9965407,0.0008543679,0.0004140903,0.001778538,0.0003065739,0.0001057463],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.0514223,0.3575176,0.007876558,0.00250918,0.003152332,0.000322069,0.01590776,0.00004038166,0.526718,0.00009531555,0.002199669,0.03223889],"study_design_scores_gemma":[0.6932529,0.01604359,0.003287863,0.000596741,0.001355001,0.00006727322,0.001101307,0.008433833,0.2735198,0.000007952895,0.002137085,0.000196688],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875494,0.001283312,0.000008565692,0.0005983652,0.0002450612,0.009750777,0.0002888207,0.00002303556,0.0002526705],"genre_scores_gemma":[0.9963539,0.0001355597,0.0004514451,0.00005314119,0.0001133814,0.0002112549,0.00008004031,0.00005036975,0.002550933],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6418306,"threshold_uncertainty_score":0.6699342,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06174651898453552,"score_gpt":0.386709169544622,"score_spread":0.3249626505600865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}