{"id":"W2987673838","doi":"10.1182/blood-2019-126509","title":"Fostamatinib, a Spleen Tyrosine Kinase (SYK) Inhibitor, for the Treatment of Warm Antibody Autoimmune Hemolytic Anemia (wAIHA): Final Results of the Phase 2, Multicenter, Open-Label Study","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Syk; Medicine; Autoimmune hemolytic anemia; Anemia; Internal medicine; Gastroenterology; Tolerability; Rituximab; Immunology; Pharmacology; Adverse effect; Tyrosine kinase; Antibody; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003034182,0.001482998,0.002280799,0.0003419718,0.0003518858,0.001239693,0.0007089397,0.001354687,0.002935509],"category_scores_gemma":[0.001602135,0.0004165231,0.002001602,0.0004108186,0.0005685184,0.001003316,0.0002928684,0.002283255,0.0007912095],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009713396,"about_ca_system_score_gemma":0.001476989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005418587,"about_ca_topic_score_gemma":0.002198442,"domain_scores_codex":[0.9991979,0.0003622444,0.00006511186,0.0001179958,0.0001278564,0.0001289273],"domain_scores_gemma":[0.9990237,0.0001913914,0.0002458295,0.00006969999,0.000162429,0.0003069424],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5361981,0.02990665,0.0154066,0.006182618,0.01036776,0.001143237,0.0006260593,0.004983447,0.06844053,0.0009291907,0.03424511,0.2915705],"study_design_scores_gemma":[0.5674504,0.3524815,0.03264726,0.0003970744,0.004234996,0.002162984,0.0001444672,0.002382944,0.01062533,0.0009712811,0.02637133,0.0001304546],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9474642,0.0274044,0.002324539,0.002692,0.0004628648,0.005952187,0.007877021,0.0002496663,0.005573174],"genre_scores_gemma":[0.9621649,0.01156827,0.003945577,0.003412735,0.0004093082,0.004301128,0.01075543,0.00008090874,0.003361757],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003034182,"threshold_uncertainty_score":0.01604652,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06174651898453552,"score_gpt":0.386709169544622,"score_spread":0.3249626505600865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}