{"id":"W2987742353","doi":"10.1182/blood-2019-129120","title":"Portia: A Phase 1b Study Evaluating Safety and Efficacy of Tisagenlecleucel and Pembrolizumab in Patients with Relapsed/Refractory Diffuse Large B-Cell Lymphoma","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"","keywords":"Pembrolizumab; Medicine; Internal medicine; Oncology; Salvage therapy; Fludarabine; Diffuse large B-cell lymphoma; Lymphoma; Cyclophosphamide; Immunotherapy; Chemotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005882411,0.0001949059,0.0004933773,0.000186917,0.0000457954,0.00001477727,0.00007909507,0.00008201497,0.0002135792],"category_scores_gemma":[0.0001076134,0.0001573873,0.00003686989,0.0002322252,0.00005870058,0.00008402346,0.00011014,0.0002033391,0.000007468752],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005259227,"about_ca_system_score_gemma":0.0001431758,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006009452,"about_ca_topic_score_gemma":0.00002465041,"domain_scores_codex":[0.9980021,0.0001601949,0.0004127771,0.0004282552,0.000651109,0.0003455424],"domain_scores_gemma":[0.9989187,0.0001862619,0.0001564658,0.0004601267,0.0001189515,0.0001595005],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01179069,0.1082404,0.8412195,0.0001888828,0.000190023,0.00007188033,0.002613883,3.626155e-7,0.01859528,0.000002161375,0.000005329578,0.0170816],"study_design_scores_gemma":[0.3910536,0.01072596,0.5963656,0.00009258924,0.0001772596,0.000009781086,0.0002998758,0.00008902122,0.001014046,0.000001455963,0.00004965948,0.0001211531],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963641,0.0004263168,0.000001618018,0.00001142954,0.0000245909,0.002066345,0.00001918013,0.00002039907,0.001066018],"genre_scores_gemma":[0.9989377,0.00005506127,0.0000648128,0.00002793681,0.00002206482,0.00001568521,0.00002424499,0.00004688352,0.00080563],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.379263,"threshold_uncertainty_score":0.641807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01485208766305775,"score_gpt":0.3048367606455959,"score_spread":0.2899846729825382,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}