{"id":"W2987742353","doi":"10.1182/blood-2019-129120","title":"Portia: A Phase 1b Study Evaluating Safety and Efficacy of Tisagenlecleucel and Pembrolizumab in Patients with Relapsed/Refractory Diffuse Large B-Cell Lymphoma","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"","keywords":"Pembrolizumab; Medicine; Internal medicine; Oncology; Salvage therapy; Fludarabine; Diffuse large B-cell lymphoma; Lymphoma; Cyclophosphamide; Immunotherapy; Chemotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002164647,0.001300658,0.001766414,0.0004301194,0.0003486855,0.001070821,0.001071944,0.0008423208,0.005805443],"category_scores_gemma":[0.001317272,0.0005749366,0.001618852,0.0003993928,0.0007475252,0.0008912724,0.0005891139,0.003740522,0.001254638],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008603045,"about_ca_system_score_gemma":0.001402628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003909401,"about_ca_topic_score_gemma":0.001018062,"domain_scores_codex":[0.9994255,0.0002942844,0.00003484951,0.0001040999,0.00006314945,0.00007810732],"domain_scores_gemma":[0.9991564,0.0001306381,0.0002057963,0.00009508373,0.00006452562,0.0003475829],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7690803,0.06714534,0.01291105,0.001369767,0.00282255,0.0003748854,0.0002266045,0.001669238,0.03468342,0.000376472,0.005908119,0.1034323],"study_design_scores_gemma":[0.6733771,0.2935374,0.01954108,0.00006301682,0.001521509,0.0006343153,0.00006354888,0.001344158,0.003272185,0.0002600995,0.006348675,0.00003692167],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9836972,0.003745558,0.0008914082,0.0006994912,0.0001953358,0.004352472,0.002401532,0.0002256008,0.003791315],"genre_scores_gemma":[0.979154,0.001957372,0.003072588,0.001541931,0.0002607762,0.005622325,0.005240158,0.00005427726,0.00309662],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005805443,"threshold_uncertainty_score":0.0194211,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01485208766305775,"score_gpt":0.3048367606455959,"score_spread":0.2899846729825382,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}