{"id":"W2987785410","doi":"10.1182/blood-2019-124320","title":"Accrual Barriers and Detection of Early Toxicity Signal in Older Less-Fit Patients Treated with Azacitidine and Nivolumab for Newly Diagnosed Acute Myeloid Leukemia (AML) or High-Risk Myelodysplastic Syndrome (MDS) in the SWOG 1612 Platform Randomized Phase II/III Clinical Trial","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; McGill University; Queen's University","funders":"","keywords":"Azacitidine; Medicine; Decitabine; Nivolumab; Internal medicine; Oncology; Myeloid leukemia; Hypomethylating agent; Myelodysplastic syndromes; Clinical trial; Cancer; Immunotherapy; Bone marrow; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01640181,0.0005855472,0.001625808,0.0003033549,0.0005229306,0.001807206,0.0008439827,0.001534247,0.005718926],"category_scores_gemma":[0.01595223,0.000375635,0.002804797,0.0004614919,0.0007105586,0.001762543,0.00104731,0.003108915,0.0005821829],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001055661,"about_ca_system_score_gemma":0.001539405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006505728,"about_ca_topic_score_gemma":0.001118901,"domain_scores_codex":[0.9921858,0.005598305,0.0005421008,0.0006344509,0.0005221841,0.000517175],"domain_scores_gemma":[0.9897299,0.004171655,0.00318577,0.0009796165,0.0004891065,0.001444123],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7452519,0.005269099,0.09698913,0.001044072,0.0046843,0.0001314709,0.0004473178,0.001983411,0.002728302,0.001741402,0.008680721,0.1310489],"study_design_scores_gemma":[0.3330194,0.2184115,0.381725,0.0008917729,0.0102091,0.0007266488,0.0003791938,0.009109747,0.003890922,0.007082645,0.03440013,0.0001538646],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.975522,0.008235571,0.001391872,0.004108223,0.00048441,0.002648451,0.00141054,0.0000761314,0.006122953],"genre_scores_gemma":[0.9916082,0.0006228094,0.001000126,0.002670167,0.0002479102,0.001900998,0.0008450649,0.00002221524,0.001082473],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01640181,"threshold_uncertainty_score":0.0867421,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02108685892739056,"score_gpt":0.2971686109966903,"score_spread":0.2760817520692998,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}