{"id":"W2987812087","doi":"10.1016/j.mayocp.2019.09.006","title":"Axicabtagene Ciloleucel Chimeric Antigen Receptor T Cell Therapy in Lymphoma With Secondary Central Nervous System Involvement","year":2019,"lang":"en","type":"letter","venue":"Mayo Clinic Proceedings","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; CancerCare Manitoba","funders":"","keywords":"Medicine; Chimeric antigen receptor; Central nervous system; Lymphoma; Antigen; Immunology; Immunotherapy; Virology; Internal medicine; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["research_integrity","insufficient_payload"],"category_scores_codex":[0.001154445,0.001098231,0.002107686,0.0007961192,0.0001202694,0.0001876327,0.0009151899,0.00150173,0.005344911],"category_scores_gemma":[0.00003752288,0.0008887896,0.0005056658,0.0009551736,0.0002649374,0.0001967156,0.0002292011,0.003284724,0.0009447667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00149463,"about_ca_system_score_gemma":0.00160512,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003302851,"about_ca_topic_score_gemma":0.000005662495,"domain_scores_codex":[0.9928644,0.00009640062,0.00142456,0.001829224,0.001793136,0.001992222],"domain_scores_gemma":[0.9974371,0.0001977169,0.0007620665,0.0008528724,0.0004278201,0.0003224645],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002948133,0.0006158618,0.02350526,0.006023293,0.0006775382,0.0007500239,0.001615695,4.39965e-7,0.0218386,0.00000240347,0.9096165,0.03240627],"study_design_scores_gemma":[0.0114478,0.004114487,0.01231866,0.001908765,0.0001168096,0.0001715994,0.001014739,0.00006658937,0.008153441,0.000005075905,0.9595566,0.001125436],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.8566257,0.002955196,0.00000525627,0.07998753,0.001685848,0.006844712,0.0001301473,0.0004810944,0.05128453],"genre_scores_gemma":[0.1409097,0.009482918,0.001156926,0.5663858,0.01696582,0.00123051,0.001922996,0.001538657,0.2604066],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.715716,"threshold_uncertainty_score":0.9998331,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03046165488987711,"score_gpt":0.2736991897576385,"score_spread":0.2432375348677613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}