{"id":"W2987822484","doi":"10.3390/molecules24213961","title":"Medically Useful Plant Terpenoids: Biosynthesis, Occurrence, and Mechanism of Action","year":2019,"lang":"en","type":"review","venue":"Molecules","topic":"Plant biochemistry and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":392,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; University of Toronto","keywords":"Terpenoid; Mevalonate pathway; Biosynthesis; Artemisinin; Mechanism (biology); Chemistry; Mechanism of action; Biology; Natural product; Computational biology; Biochemistry; Gene; In vitro; Malaria; Plasmodium falciparum","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002047404,0.0004402676,0.0009363551,0.00009302604,0.00004559814,0.00002405306,0.0003828399,0.0007611733,0.00002538036],"category_scores_gemma":[0.0001481347,0.000346646,0.0002989502,0.00009141812,0.0001276512,0.000003007463,0.0001941926,0.0001835092,0.00001768713],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001223839,"about_ca_system_score_gemma":0.0001825362,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005805813,"about_ca_topic_score_gemma":0.000005195164,"domain_scores_codex":[0.9982882,0.0001230268,0.0004700134,0.0006334357,0.0002158272,0.0002695076],"domain_scores_gemma":[0.9989275,0.00006911373,0.0003864348,0.0004708445,0.00003409651,0.0001119923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009540725,0.0002156932,0.00001343117,0.0305617,0.0007850054,0.0000374133,0.00001216724,2.096289e-7,0.1750217,0.0001955425,0.006820735,0.7862409],"study_design_scores_gemma":[0.00009379317,0.0001112095,0.000001732436,0.002435654,0.0005045295,0.0001432819,0.000008776501,0.000003089137,0.1553817,0.00001222735,0.8409032,0.0004008355],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001009306,0.9953349,0.0001258278,0.00001918873,0.0001691236,0.0003399235,0.002576235,0.00001590418,0.0004096453],"genre_scores_gemma":[0.001856608,0.9957284,0.0001662944,0.00003739661,0.0001267839,0.00002601467,0.001825738,0.00002830501,0.0002045147],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8340824,"threshold_uncertainty_score":0.9998986,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04827800888921886,"score_gpt":0.2947961188693827,"score_spread":0.2465181099801638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}