{"id":"W2987822484","doi":"10.3390/molecules24213961","title":"Medically Useful Plant Terpenoids: Biosynthesis, Occurrence, and Mechanism of Action","year":2019,"lang":"en","type":"review","venue":"Molecules","topic":"Plant biochemistry and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":392,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; University of Toronto","keywords":"Terpenoid; Mevalonate pathway; Biosynthesis; Artemisinin; Mechanism (biology); Chemistry; Mechanism of action; Biology; Natural product; Computational biology; Biochemistry; Gene; In vitro; Malaria; Plasmodium falciparum","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002115021,0.0006849833,0.000684551,0.002201528,0.0002265894,0.0006997589,0.0004098221,0.0005458359,0.00395655],"category_scores_gemma":[0.0003008059,0.0002314129,0.0003044295,0.001914875,0.0002715994,0.0009788554,0.0004337127,0.001038944,0.0021639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004639618,"about_ca_system_score_gemma":0.0006786861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008432653,"about_ca_topic_score_gemma":0.00130548,"domain_scores_codex":[0.9999151,0.00001033765,0.00001176366,0.00002041032,0.00003144314,0.00001089894],"domain_scores_gemma":[0.9998728,0.00005358541,0.00002404567,0.00000560948,0.00003008981,0.00001387978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007335254,0.00005447055,0.0001742765,0.01718863,0.00005100402,0.0002042222,0.00005927476,0.000434238,0.008041376,0.003522205,0.01397896,0.956218],"study_design_scores_gemma":[0.000005564536,0.00005926529,0.000621377,0.001464398,0.00005950366,0.0009065328,0.00004396719,0.00006058301,0.001603041,0.001235868,0.9939278,0.00001199383],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002890268,0.9971711,0.0001767392,0.0001399704,0.0001127772,0.000004103423,0.00003874955,0.0000123592,0.002055238],"genre_scores_gemma":[0.001252618,0.9972019,0.0002415746,0.00008716665,0.00007136091,0.000004328562,0.00005209586,0.000001957973,0.001087035],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00395655,"threshold_uncertainty_score":0.01323599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04827800888921886,"score_gpt":0.2947961188693827,"score_spread":0.2465181099801638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}