{"id":"W2987826698","doi":"10.1016/j.ymeth.2019.11.003","title":"Emerging tools to investigate bromodomain functions","year":2019,"lang":"en","type":"review","venue":"Methods","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Medical Research Council; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Wellcome Trust","keywords":"Interactome; Bromodomain; Computational biology; Biology; Epigenetics; Histone; Proteomics; Biotinylation; Chromatin remodeling; Cell biology; Genetics; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002188899,0.002032136,0.001848142,0.002964202,0.0003833029,0.001482732,0.001865791,0.001701602,0.002818029],"category_scores_gemma":[0.001347897,0.0007117955,0.0006896217,0.002113449,0.001575766,0.002115281,0.001213031,0.004283605,0.002563042],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001512055,"about_ca_system_score_gemma":0.001089718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009436337,"about_ca_topic_score_gemma":0.001458703,"domain_scores_codex":[0.9995059,0.00007439847,0.00004563959,0.00009769035,0.0002147286,0.0000616588],"domain_scores_gemma":[0.9993223,0.0003720783,0.00006405354,0.00004337152,0.0001381738,0.0000600062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001930201,0.0001444442,0.000202152,0.01474626,0.0001186634,0.0002102543,0.00005970508,0.00094411,0.02458793,0.02145221,0.03463759,0.9027038],"study_design_scores_gemma":[0.00003841488,0.00008845502,0.0004075148,0.001023664,0.0001022098,0.0007369238,0.00003033305,0.000387238,0.01029968,0.006344247,0.9805022,0.00003916067],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002028147,0.9925339,0.004160537,0.000329374,0.000442011,0.00001418031,0.00005538113,0.00006329654,0.0021984],"genre_scores_gemma":[0.001398876,0.9914702,0.003936286,0.0004405562,0.0003163468,0.00004188031,0.000137205,0.00001363081,0.002245067],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002964202,"threshold_uncertainty_score":0.01157618,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1396728694799902,"score_gpt":0.4531333163461242,"score_spread":0.3134604468661341,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}