{"id":"W2987842064","doi":"10.1016/j.tcb.2019.10.003","title":"Wnt Signaling in 3D: Recent Advances in the Applications of Intestinal Organoids","year":2019,"lang":"en","type":"review","venue":"Trends in Cell Biology","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":112,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"H2020 European Research Council; European Research Council; Seventh Framework Programme; KWF Kankerbestrijding; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; ZonMw; European Commission; Marie Curie; Echo Foundation","keywords":"Biology; Organoid; Wnt signaling pathway; Computational biology; Cell biology; Signal transduction","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008448666,0.0008268902,0.001301441,0.00172712,0.0002013782,0.001547207,0.0007579282,0.0009864296,0.003214917],"category_scores_gemma":[0.0006920106,0.0003207726,0.0005156433,0.001919924,0.0006318986,0.00121475,0.0007933662,0.001839052,0.001472817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007686467,"about_ca_system_score_gemma":0.0009676675,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001438529,"about_ca_topic_score_gemma":0.002745791,"domain_scores_codex":[0.9997929,0.0000298583,0.00002475888,0.00003635487,0.00008963357,0.00002656286],"domain_scores_gemma":[0.9996312,0.0001897484,0.00004186504,0.00001276434,0.00008577444,0.00003873398],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000149445,0.00006072933,0.0002178031,0.01246581,0.00006337959,0.0001868427,0.00005367427,0.0007472095,0.007938045,0.007949257,0.01792118,0.9522467],"study_design_scores_gemma":[0.00001977914,0.00009604323,0.0006125769,0.001622397,0.0001130089,0.0005958909,0.00005639702,0.0002453015,0.002637723,0.002396943,0.9915749,0.00002906139],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002292544,0.9978053,0.0004001904,0.0002724651,0.000159818,0.000004148883,0.00003298103,0.00001286226,0.001082926],"genre_scores_gemma":[0.0009193235,0.9979345,0.0003597288,0.0001456096,0.00009623536,0.000004607884,0.00004152058,0.000002418778,0.0004961081],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003214917,"threshold_uncertainty_score":0.010755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07971825948788533,"score_gpt":0.4003987434763693,"score_spread":0.3206804839884839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}