{"id":"W2987862994","doi":"10.1136/bmjopen-2019-029449","title":"Study protocol for a randomised, double-blind, placebo-controlled study evaluating the Efficacy of cannabis-based Medicine Extract in slowing the disease pRogression of Amyotrophic Lateral sclerosis or motor neurone Disease: the EMERALD trial","year":2019,"lang":"en","type":"article","venue":"BMJ Open","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Amyotrophic lateral sclerosis; Placebo; Cannabis; Clinical trial; Cannabidiol; Disease; Internal medicine; Physical therapy; Psychiatry; Pathology; Alternative medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01634195,0.006110635,0.01013585,0.001809509,0.003321168,0.003378569,0.003180518,0.007393952,0.1569365],"category_scores_gemma":[0.02096251,0.003085107,0.003946258,0.002388294,0.00279357,0.003243906,0.001544179,0.007854774,0.02914434],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002936821,"about_ca_system_score_gemma":0.01216777,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001755275,"about_ca_topic_score_gemma":0.003480259,"domain_scores_codex":[0.9898671,0.004917525,0.001241954,0.001571674,0.001243053,0.001158692],"domain_scores_gemma":[0.99019,0.002408271,0.001673202,0.001465958,0.002206435,0.002056218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8773215,0.008732312,0.001009066,0.02035085,0.001466481,0.000317232,0.0003097315,0.001067212,0.001910857,0.005463263,0.04400448,0.03804693],"study_design_scores_gemma":[0.898699,0.02065409,0.002136916,0.003286479,0.0007910823,0.00007825407,0.0001024379,0.001202825,0.0005713158,0.003095156,0.06927317,0.0001092784],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.001694892,0.000703688,0.001430258,0.0003168016,0.0009362592,0.9881846,0.004243638,0.0001613549,0.002328534],"genre_scores_gemma":[0.002784732,0.0002503768,0.001656017,0.0004060149,0.0001464966,0.9930803,0.0005234353,0.00001127536,0.001141312],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.1569365,"threshold_uncertainty_score":0.525005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2891636274216169,"score_gpt":0.5267676917766968,"score_spread":0.2376040643550799,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}