{"id":"W2987889066","doi":"10.1182/blood-2019-123048","title":"Hematologic Improvement-Neutrophil and -Platelet in the MEDALIST Trial: Multilineage Data from a Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Luspatercept to Treat Anemia in Patients with Very Low-, Low-, or Intermediate-Risk Myelodysplastic Syndromes (MDS) with Ring Sideroblasts (RS) Who Require Red Blood Cell (RBC) Transfusions","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Hematological disorders and diagnostics","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Internal medicine; Anemia; Myelodysplastic syndromes; Placebo; Cytopenia; Erythropoiesis; International Prognostic Scoring System; Surrogate endpoint; Gastroenterology; Surgery; Bone marrow; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007464048,0.000601084,0.002769147,0.0003408875,0.00008177937,0.0000662365,0.0004834485,0.0002298481,0.0001102856],"category_scores_gemma":[0.000912592,0.0003015142,0.0001032027,0.0004756757,0.0001690166,0.0002256365,0.0001951031,0.0004978285,0.000006598119],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002411566,"about_ca_system_score_gemma":0.0001200998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008168792,"about_ca_topic_score_gemma":0.002578866,"domain_scores_codex":[0.9958804,0.0004886821,0.001429287,0.001026688,0.000622801,0.0005521621],"domain_scores_gemma":[0.9948546,0.00323244,0.0004715415,0.001103426,0.0001025519,0.0002354513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.925716,0.02644278,0.04266298,0.0005120598,0.0003791936,0.0009701964,0.002716709,0.0001328516,0.0003875019,0.000001384845,0.00000806036,0.00007027926],"study_design_scores_gemma":[0.9714497,0.01671907,0.003961594,0.001139033,0.002184995,0.00002324748,0.002686644,0.000603028,0.0008534605,0.000008046436,5.444181e-7,0.0003706138],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9817362,0.00008704862,0.00002747991,0.00007648337,0.00006293721,0.01762115,0.0002933608,0.00004418701,0.00005116551],"genre_scores_gemma":[0.9983703,0.0001561054,0.0001484127,0.0001002087,0.00002492218,0.0008495025,0.000270268,0.0000574098,0.00002280591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04573372,"threshold_uncertainty_score":0.9999437,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02220109748229372,"score_gpt":0.2782372666944529,"score_spread":0.2560361692121592,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}