{"id":"W2987889066","doi":"10.1182/blood-2019-123048","title":"Hematologic Improvement-Neutrophil and -Platelet in the MEDALIST Trial: Multilineage Data from a Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Luspatercept to Treat Anemia in Patients with Very Low-, Low-, or Intermediate-Risk Myelodysplastic Syndromes (MDS) with Ring Sideroblasts (RS) Who Require Red Blood Cell (RBC) Transfusions","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Hematological disorders and diagnostics","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Internal medicine; Anemia; Myelodysplastic syndromes; Placebo; Cytopenia; Erythropoiesis; International Prognostic Scoring System; Surrogate endpoint; Gastroenterology; Surgery; Bone marrow; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00196361,0.0009931513,0.0015887,0.0002698836,0.0003615437,0.0009375401,0.0005865191,0.0009860623,0.005825668],"category_scores_gemma":[0.001290009,0.0002546578,0.001753345,0.0003164339,0.0007244767,0.0006840028,0.0003133633,0.002348277,0.000592534],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004143011,"about_ca_system_score_gemma":0.0006991283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003153542,"about_ca_topic_score_gemma":0.0012311,"domain_scores_codex":[0.9993867,0.0003275953,0.00004849346,0.00008366719,0.00007703242,0.00007653885],"domain_scores_gemma":[0.9992367,0.0001635796,0.0002716323,0.00005216314,0.00006096373,0.0002149981],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9440786,0.005777071,0.001706763,0.002135253,0.002599061,0.0001013714,0.00006898586,0.0005420565,0.007551291,0.0003069155,0.004340734,0.03079182],"study_design_scores_gemma":[0.917,0.06988579,0.006523232,0.0001015639,0.001569938,0.0001586696,0.00002748081,0.0004416907,0.001278087,0.000254254,0.002735826,0.00002342707],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9599946,0.02066719,0.001083693,0.0022498,0.0005933322,0.003643035,0.004331427,0.0001933668,0.00724361],"genre_scores_gemma":[0.9810641,0.004668035,0.001398705,0.002368148,0.0004886955,0.002691971,0.004204431,0.00002513614,0.003090676],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005825668,"threshold_uncertainty_score":0.01948881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02220109748229372,"score_gpt":0.2782372666944529,"score_spread":0.2560361692121592,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}