{"id":"W2987891747","doi":"10.1182/blood-2019-126287","title":"The Splicing Factor RBM17 Supports Leukemia Stem Cell Self-Renewal","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Spliceosome; RNA splicing; Biology; Splicing factor; Myeloid leukemia; Stem cell; Alternative splicing; Genetics; Intron; Leukemia; SR protein; Cancer research; Gene; RNA; Messenger RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004402601,0.0003724159,0.0004356497,0.001242634,0.0002903211,0.0005981529,0.0002816455,0.0002493963,0.002221708],"category_scores_gemma":[0.001022923,0.0001227023,0.0005467362,0.001184793,0.0003931483,0.0002378933,0.000368587,0.000258836,0.001288266],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003191366,"about_ca_system_score_gemma":0.0006913043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005810164,"about_ca_topic_score_gemma":0.001113284,"domain_scores_codex":[0.9996841,0.00003104802,0.00003961547,0.00007288609,0.0001122281,0.00006019814],"domain_scores_gemma":[0.9989585,0.0001685528,0.0005216323,0.00008698092,0.0001301854,0.0001342761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001340477,0.00007655833,0.4147392,0.000971876,0.0003643102,0.001576495,0.0002501693,0.0009655372,0.5252919,0.0008224887,0.001459881,0.05214115],"study_design_scores_gemma":[0.00006645054,0.000601955,0.4945614,0.0002584011,0.000653632,0.008519983,0.0005247863,0.004829431,0.4519924,0.001529735,0.03642372,0.00003810352],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891382,0.004200426,0.001944373,0.0001002403,0.00001832571,0.00001894857,0.002832278,0.0001587945,0.001588569],"genre_scores_gemma":[0.9888862,0.001943401,0.002596036,0.00004878321,0.00002044981,0.00001793412,0.006044014,0.00003600618,0.0004071446],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002221708,"threshold_uncertainty_score":0.007432342,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005504000948988499,"score_gpt":0.2216913148955582,"score_spread":0.2161873139465697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}