{"id":"W2987978838","doi":"10.1101/840132","title":"Loss of m <sup>1</sup> acp <sup>3</sup> Ψ ribosomal RNA modification is a major feature of cancer","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of Lethbridge; Terry Fox Research Institute; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Genentech; University of British Columbia; Alberta Innovates; Leukemia and Lymphoma Society of Canada; National Cancer Institute; Amazon Web Services; Leukemia and Lymphoma Society","keywords":"Ribosomal RNA; Ribosome; Pseudouridine; RNA; Ribosomal protein; Biology; 23S ribosomal RNA; 5.8S ribosomal RNA; Genetics; Molecular biology; Gene; Transfer RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001412641,0.0002860223,0.0001807713,0.000224481,0.0001921815,0.0003632128,0.0001791578,0.0003517671,0.00171683],"category_scores_gemma":[0.0001969054,0.0001215923,0.0001777019,0.0001589606,0.0004104203,0.0001440438,0.0002088301,0.0007212259,0.0006051349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003980525,"about_ca_system_score_gemma":0.0002117159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005595368,"about_ca_topic_score_gemma":0.0005791605,"domain_scores_codex":[0.999822,0.00002066317,0.00001346089,0.0000502084,0.00006559899,0.00002817954],"domain_scores_gemma":[0.9998266,0.00001730092,0.00008217479,0.00002298213,0.0000124739,0.00003851543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001699763,0.00002065869,0.00209461,0.00003881302,0.00001089112,0.000187852,0.0000100693,0.0001181109,0.9923276,0.0003811526,0.0004710142,0.004169091],"study_design_scores_gemma":[0.00001997015,0.0003089735,0.03284276,0.00001412365,0.00002509979,0.002510757,0.00005318137,0.00127609,0.9482107,0.0005013816,0.01422558,0.00001138966],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855776,0.003564793,0.004702463,0.0007625298,0.0001232899,0.00004137524,0.001238189,0.0003303881,0.003659381],"genre_scores_gemma":[0.9941618,0.0006963428,0.001473978,0.0001749897,0.00002418244,0.00002843018,0.0009726098,0.00003523915,0.002432502],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00171683,"threshold_uncertainty_score":0.005743325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01226094429358389,"score_gpt":0.2454209798375366,"score_spread":0.2331600355439527,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}