{"id":"W2987989330","doi":"10.1093/neuonc/noz175.968","title":"RARE-45. ACTIVITY OF LAROTRECTINIB IN TRK FUSION CANCER PATIENTS WITH PRIMARY CENTRAL NERVOUS SYSTEM TUMORS","year":2019,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Trk receptor; Medicine; Internal medicine; Oncology; Cancer; Neurotrophin; Gastroenterology; Surgery; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004677499,0.0002076907,0.0006651173,0.00029193,0.0002567524,0.0004620388,0.0001664019,0.0001677652,0.003169511],"category_scores_gemma":[0.0006141631,0.00007830934,0.0004578162,0.0004068059,0.0001912582,0.0002076632,0.000235224,0.000365169,0.0005631977],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007432494,"about_ca_system_score_gemma":0.0005468576,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001247786,"about_ca_topic_score_gemma":0.004057453,"domain_scores_codex":[0.9996369,0.00007784808,0.00005108703,0.00007685708,0.00007475646,0.00008254915],"domain_scores_gemma":[0.9996156,0.00007984082,0.0001162752,0.00002437154,0.00006203628,0.0001017731],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.02185702,0.001574562,0.5533412,0.001120965,0.000963987,0.00405057,0.0002916499,0.00176295,0.09162529,0.0003913217,0.01415991,0.3088607],"study_design_scores_gemma":[0.005193258,0.03363385,0.8581282,0.0002248363,0.00161855,0.01863508,0.0002974522,0.003198973,0.04252353,0.0006370468,0.03585067,0.00005845667],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9831965,0.00517002,0.0003833341,0.0002811621,0.00003260152,0.0001975489,0.002688527,0.0001009989,0.007949235],"genre_scores_gemma":[0.9955374,0.0007706349,0.0004942165,0.0001979447,0.00002970565,0.00006863565,0.002110235,0.000007126066,0.0007841099],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003169511,"threshold_uncertainty_score":0.01060307,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009831218568027171,"score_gpt":0.2539904531444316,"score_spread":0.2441592345764045,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}