{"id":"W2988003492","doi":"10.1182/blood-2019-122590","title":"High Rate of IDH1 Mutation Clearance and Measurable Residual Disease Negativity in Patients with IDH1-Mutant Newly Diagnosed Acute Myeloid Leukemia Treated with Ivosidenib (AG-120) and Azacitidine","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Myeloid leukemia; IDH1; Medicine; Isocitrate dehydrogenase; Internal medicine; Myeloid; Peripheral blood mononuclear cell; Minimal residual disease; Bone marrow; Azacitidine; Oncology; Gastroenterology; Mutation; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004344772,0.0001363576,0.0003777848,0.0002580172,0.0002201395,0.0004338149,0.0002274045,0.0003071929,0.0008469223],"category_scores_gemma":[0.001690242,0.0001126956,0.0001442992,0.0002208292,0.0001924723,0.0002338699,0.0001943604,0.0004376245,0.0001472668],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002736692,"about_ca_system_score_gemma":0.0001957215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000599571,"about_ca_topic_score_gemma":0.0006833392,"domain_scores_codex":[0.9996858,0.00008294785,0.00002829448,0.00009104654,0.00007164873,0.00004041017],"domain_scores_gemma":[0.9991202,0.0002958621,0.0003177075,0.00006593396,0.00006175391,0.0001386987],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002599941,0.0001580335,0.9775463,0.00002394652,0.00004526514,0.001039332,0.0001627856,0.0001561965,0.006678411,0.00004572831,0.0002357357,0.01130824],"study_design_scores_gemma":[0.00008206072,0.001378588,0.9911829,0.000006316153,0.00004729495,0.004171937,0.0001242816,0.0007316219,0.001371065,0.0000469014,0.0008508503,0.000006235464],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990889,0.0003117287,0.0001249404,0.00003035209,0.000003974447,0.00001420144,0.00008719926,0.000005885975,0.0003329454],"genre_scores_gemma":[0.9996928,0.00003663465,0.00004555306,0.00002164417,0.000005716071,0.000004416234,0.0001147612,0.000001331812,0.00007727479],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008469223,"threshold_uncertainty_score":0.002833247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006214044789194348,"score_gpt":0.2171106474423607,"score_spread":0.2108966026531664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}