{"id":"W2988024237","doi":"10.1128/jvi.01688-19","title":"Single Amino Acid Differences between Closely Related Reovirus T3D Lab Strains Alter Oncolytic Potency <i>In Vitro</i> and <i>In Vivo</i>","year":2019,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Izaak Walton Killam Health Centre; Dalhousie University; University of Alberta","funders":"Canadian Institutes of Health Research; Canada Foundation for Innovation; Canada Research Chairs; Government of Canada","keywords":"Oncolytic virus; Biology; Potency; In vivo; In vitro; Virology; Cancer therapy; Virus; Serotype; Amino acid; Melanoma; Strain (injury); Cancer research; Cancer; Molecular biology; Microbiology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001825049,0.0003053335,0.000210828,0.0001821386,0.0001166128,0.0003078901,0.0002045375,0.0003254507,0.001091828],"category_scores_gemma":[0.0003238842,0.00009190174,0.0004562941,0.0001863798,0.0002956396,0.0001931951,0.0001558881,0.0008561119,0.0003136057],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002936479,"about_ca_system_score_gemma":0.0001679829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007414614,"about_ca_topic_score_gemma":0.0006612026,"domain_scores_codex":[0.9998172,0.00004994174,0.00002794002,0.00003681445,0.00003219298,0.00003600457],"domain_scores_gemma":[0.9996723,0.0001094755,0.0001007112,0.00004305806,0.000018232,0.00005621745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002242926,0.00003944606,0.0004258865,0.00001301081,0.00001282952,0.00003541274,0.000008255462,0.00009738583,0.9983221,0.0000627966,0.00002099481,0.0007375823],"study_design_scores_gemma":[0.00001795625,0.0006919057,0.006079249,0.000004687744,0.00003824246,0.0004248571,0.00003519921,0.0005208708,0.9912931,0.00006254141,0.0008225823,0.000008715225],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970981,0.0003425586,0.001465912,0.00004135353,0.00001935238,0.0000143743,0.000347387,0.00002482363,0.0006461613],"genre_scores_gemma":[0.9964965,0.000208128,0.001975993,0.00005955954,0.000005096927,0.00001667374,0.0007548894,0.00004498402,0.0004382558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001091828,"threshold_uncertainty_score":0.003652573,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01631223309604764,"score_gpt":0.2747456525279864,"score_spread":0.2584334194319388,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}