{"id":"W2988024237","doi":"10.1128/jvi.01688-19","title":"Single Amino Acid Differences between Closely Related Reovirus T3D Lab Strains Alter Oncolytic Potency <i>In Vitro</i> and <i>In Vivo</i>","year":2019,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Izaak Walton Killam Health Centre; Dalhousie University; University of Alberta","funders":"Canadian Institutes of Health Research; Canada Foundation for Innovation; Canada Research Chairs; Government of Canada","keywords":"Oncolytic virus; Biology; Potency; In vivo; In vitro; Virology; Cancer therapy; Virus; Serotype; Amino acid; Melanoma; Strain (injury); Cancer research; Cancer; Molecular biology; Microbiology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007409963,0.0002038659,0.0004917305,0.0002472283,0.00003026677,0.0000220575,0.000338042,0.0003465493,0.00007261617],"category_scores_gemma":[0.0000636342,0.0001772015,0.0001045995,0.0001655644,0.0001579608,0.00001594704,0.0001030916,0.0005178305,0.0000133292],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005433512,"about_ca_system_score_gemma":0.0001603652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001999446,"about_ca_topic_score_gemma":0.0001541402,"domain_scores_codex":[0.9979675,0.0003775065,0.0006424467,0.0003240808,0.0002305797,0.0004579008],"domain_scores_gemma":[0.9991788,0.00006160244,0.0002905887,0.0002624813,0.00007307615,0.0001334194],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002297741,0.0001538085,0.02654125,0.0000150057,0.00007874154,0.00007045624,0.0000872514,0.00002387256,0.9673938,0.000003163123,0.0000817952,0.003253162],"study_design_scores_gemma":[0.003832531,0.009447532,0.03159497,0.0000302286,0.00002995488,0.0001545166,0.00006932117,0.00004180436,0.9529268,0.0003887404,0.00123368,0.0002499289],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962805,0.001930886,0.00001422253,0.00083803,0.0001419108,0.0001894528,0.00002140012,0.000003490673,0.0005801067],"genre_scores_gemma":[0.9983648,0.000478625,0.0001120938,0.0004671314,0.0001655492,0.000003244631,0.000007352822,0.00002655706,0.000374618],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01446696,"threshold_uncertainty_score":0.7226067,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01631223309604764,"score_gpt":0.2747456525279864,"score_spread":0.2584334194319388,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}