{"id":"W2988067761","doi":"10.1093/neuonc/noz217","title":"Targeting MEK/MELK in atypical teratoid rhabdoid tumor: a treatment approach aimed at exploiting blood–brain barrier deficiencies","year":2019,"lang":"en","type":"letter","venue":"Neuro-Oncology","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; University of Toronto; Hospital for Sick Children; Occupational Cancer Research Centre","funders":"","keywords":"Blood–brain barrier; Medicine; Cancer research; Neuroscience; Psychology; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007194997,0.0004437941,0.0006224301,0.0003303687,0.001086712,0.001334167,0.0005174998,0.01568039,0.002895723],"category_scores_gemma":[0.003596766,0.0002838317,0.0005996064,0.0002247718,0.001025796,0.0008642302,0.0004939671,0.01072372,0.001858248],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002376953,"about_ca_system_score_gemma":0.001102791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001389785,"about_ca_topic_score_gemma":0.002526725,"domain_scores_codex":[0.9996058,0.00009421984,0.00004642006,0.00004979139,0.0001236053,0.00008018907],"domain_scores_gemma":[0.9991247,0.0004863564,0.00007451534,0.00003542138,0.0001168892,0.0001620753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004943315,0.0001459447,0.00131604,0.0001799188,0.00004753069,0.01476905,0.00007972641,0.0004612629,0.003307972,0.007753473,0.9296355,0.04180938],"study_design_scores_gemma":[0.0007116098,0.0003535872,0.002034972,0.0001936961,0.00008119046,0.01306228,0.0001204301,0.002534537,0.004726938,0.01585897,0.9602535,0.00006838056],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.003851133,0.006615428,0.000595364,0.9491056,0.0325212,0.00004428536,0.0001215111,0.00007374783,0.007071792],"genre_scores_gemma":[0.06844146,0.0136214,0.001693281,0.7778506,0.09881044,0.0002455186,0.0001414676,0.00005853688,0.03913737],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01568039,"threshold_uncertainty_score":0.01724613,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01832956537006684,"score_gpt":0.2599852776626149,"score_spread":0.241655712292548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}