{"id":"W2988092601","doi":"10.1001/jamadermatol.2019.3336","title":"Efficacy and Safety of Dupilumab in Adolescents With Uncontrolled Moderate to Severe Atopic Dermatitis","year":2019,"lang":"en","type":"article","venue":"JAMA Dermatology","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":509,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; Probity Medical Research; SKiN Health","funders":"Sanofi Genzyme; LEO Pharma; Les Laboratories Pierre Fabre; Regeneron Pharmaceuticals; Sanofi; Pfizer; Eli Lilly and Company","keywords":"Medicine; Dupilumab; Eczema Area and Severity Index; Atopic dermatitis; Randomized controlled trial; Dermatology Life Quality Index; SCORAD; Placebo; Internal medicine; Population; Quality of life (healthcare); Clinical endpoint; Pediatrics; Dermatology; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001532932,0.0003269179,0.001097505,0.0001666162,0.0003063777,0.0004697422,0.0003502537,0.0005584134,0.001571557],"category_scores_gemma":[0.001672597,0.0002137817,0.0006809559,0.000192651,0.0004526102,0.000316845,0.0001775483,0.0009945835,0.0001840417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006813889,"about_ca_system_score_gemma":0.001421172,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001738331,"about_ca_topic_score_gemma":0.005881751,"domain_scores_codex":[0.9994419,0.0002726061,0.00005945852,0.00006542852,0.00009918399,0.00006139691],"domain_scores_gemma":[0.9990147,0.0003042225,0.0003091273,0.00004469361,0.00008224419,0.0002448572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7721696,0.02215858,0.0458169,0.001781985,0.001564401,0.0001874795,0.000240725,0.0008448313,0.02291607,0.0001568737,0.001425167,0.1307374],"study_design_scores_gemma":[0.3678634,0.4960859,0.1240253,0.0002175784,0.001872284,0.0004402282,0.0001663374,0.001411619,0.005184878,0.0001347056,0.002571071,0.00002665675],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964557,0.00214174,0.0001094794,0.00007362286,0.0000285489,0.0005202083,0.0001709745,0.0000102517,0.000489411],"genre_scores_gemma":[0.9980316,0.0007296641,0.0003745285,0.0001290407,0.00004287046,0.0003290472,0.0001483752,0.000001602841,0.0002132731],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001738331,"threshold_uncertainty_score":0.008107007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005197194933641165,"score_gpt":0.231256539369391,"score_spread":0.2260593444357498,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}