{"id":"W2988163208","doi":"10.1016/b978-0-12-816434-1.00002-4","title":"Efflux transporters in anti-cancer drug resistance: Molecular and functional identification and characterization of multidrug resistance proteins (MRPs/ABCCs)","year":2019,"lang":"en","type":"book-chapter","venue":"Elsevier eBooks","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"ABCC1; Subfamily; Efflux; ATP-binding cassette transporter; Abcg2; Multiple drug resistance; Biology; Drug resistance; Transporter; Cancer; Drug; Multidrug Resistance-Associated Proteins; Identification (biology); Solute carrier family; Computational biology; Pharmacology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002205553,0.0006464889,0.000610256,0.001103214,0.0002804063,0.001901479,0.0006019346,0.001006493,0.02064204],"category_scores_gemma":[0.0001833879,0.0003160197,0.0003621508,0.001564436,0.0004179187,0.001927444,0.000573095,0.001926958,0.01762621],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005395125,"about_ca_system_score_gemma":0.0005232704,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007017198,"about_ca_topic_score_gemma":0.001272016,"domain_scores_codex":[0.9999048,0.000008079003,0.000004430324,0.0000215607,0.00005018461,0.00001105464],"domain_scores_gemma":[0.9999315,0.00002434641,0.000005824373,0.000004720118,0.00002292268,0.00001073919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001370435,0.0001885675,0.0002530921,0.001365313,0.00001687263,0.0003015694,0.0002294106,0.0005474374,0.08341543,0.0579891,0.1269644,0.7285918],"study_design_scores_gemma":[0.000006647488,0.00005983441,0.0005329361,0.0001770441,0.000009207497,0.0005655454,0.00003593437,0.0002431651,0.007016602,0.005259464,0.9860853,0.000008268563],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.006147608,0.7529906,0.01692588,0.004953141,0.003019656,0.00008745545,0.0007365404,0.0003774864,0.2147617],"genre_scores_gemma":[0.01441481,0.4060652,0.01272593,0.001600394,0.0008974631,0.00007849322,0.0009645367,0.0001352101,0.563118],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.02064204,"threshold_uncertainty_score":0.06905448,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007876860986267603,"score_gpt":0.2158591156506023,"score_spread":0.2079822546643347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}