{"id":"W2988183880","doi":"10.1182/blood-2019-123949","title":"Dual CD20-Targeted Therapy With Concurrent CD20-TCB and Obinutuzumab Shows Highly Promising Clinical Activity and Manageable Safety in Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma: Preliminary Results From a Phase Ib Trial","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Obinutuzumab; Medicine; CD20; Refractory (planetary science); Lymphoma; Oncology; Phases of clinical research; Rituximab; Internal medicine; Clinical trial; Cancer research; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007699325,0.0007182909,0.001383608,0.0002611351,0.0002047002,0.0007976214,0.0005673084,0.0006649233,0.001484387],"category_scores_gemma":[0.0003900236,0.0002199144,0.0006332699,0.0003560711,0.000487249,0.0005491399,0.0003465308,0.002151722,0.0004406376],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007789377,"about_ca_system_score_gemma":0.0006599535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008089939,"about_ca_topic_score_gemma":0.002090542,"domain_scores_codex":[0.9997985,0.00005335824,0.00001263653,0.00004129883,0.00003763103,0.00005660044],"domain_scores_gemma":[0.999761,0.00003359171,0.00003944006,0.00002090439,0.00001844102,0.0001265635],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2116866,0.04004325,0.006645742,0.001419421,0.001569835,0.0008788632,0.0005479167,0.003619675,0.2245832,0.0007510343,0.006351295,0.5019032],"study_design_scores_gemma":[0.2920424,0.5431377,0.02915435,0.0002421249,0.001793808,0.003099025,0.0002107389,0.006894359,0.09357814,0.0009378184,0.02881519,0.00009440553],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866904,0.008874878,0.0009870459,0.000413542,0.00008356985,0.0004414385,0.0003980355,0.0001536745,0.001957458],"genre_scores_gemma":[0.9914486,0.003486879,0.001244328,0.0004346537,0.00006950821,0.0003439559,0.001398201,0.00003146632,0.001542487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001484387,"threshold_uncertainty_score":0.005651653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03937115457596355,"score_gpt":0.3341516338312315,"score_spread":0.2947804792552679,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}