{"id":"W2988190468","doi":"10.1182/blood-2019-127839","title":"NUP98-HOXA9-Initiates Molecular and Biologic Features of Disease Progression in a Humanized Model of CML","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia; BC Cancer Agency","funders":"","keywords":"Clonogenic assay; Myeloid leukemia; Haematopoiesis; Cancer research; Myeloid; Stem cell; Biology; CD34; Progenitor cell; Immunology; Leukemia; clone (Java method); Cell culture; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002654987,0.0004454874,0.0003576193,0.0004670243,0.0002095917,0.0004358468,0.0003387814,0.0005808339,0.002311859],"category_scores_gemma":[0.0001459669,0.0002245279,0.0003197973,0.0001831786,0.0004649903,0.0002448264,0.0002856334,0.001205372,0.0005338801],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000407812,"about_ca_system_score_gemma":0.000236943,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000455726,"about_ca_topic_score_gemma":0.0003847673,"domain_scores_codex":[0.999741,0.00005729062,0.00002714017,0.00007046261,0.00006152649,0.00004258789],"domain_scores_gemma":[0.999862,0.00002143386,0.00004311542,0.0000251521,0.000005634925,0.00004271014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009015537,0.0005630373,0.0002044615,0.00002818071,0.000006201052,0.000313601,0.00004238753,0.0002816713,0.9953291,0.000499913,0.0001462574,0.001683742],"study_design_scores_gemma":[0.000525975,0.007517079,0.004981766,0.00002116393,0.0000313155,0.002892845,0.0000927432,0.006356152,0.9691924,0.0004559033,0.007914881,0.00001779137],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951606,0.0005182322,0.001853432,0.0001614595,0.00006441116,0.0001250001,0.0007169902,0.0001039314,0.001295933],"genre_scores_gemma":[0.9939694,0.0003523988,0.001958148,0.00006441277,0.00001334405,0.0001387027,0.0006514626,0.00002131673,0.002830768],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002311859,"threshold_uncertainty_score":0.007733941,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01325152242972903,"score_gpt":0.2745262500575751,"score_spread":0.2612747276278461,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}