{"id":"W2988218846","doi":"10.1124/dmd.119.088229","title":"Glucuronidation of Abiraterone and Its Pharmacologically Active Metabolites by UGT1A4, Influence of Polymorphic Variants and Their Potential as Inhibitors of Steroid Glucuronidation","year":2019,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval; Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research; Université Laval","keywords":"Glucuronidation; Pharmacology; Chemistry; Medicine; Microsome; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004484039,0.0002587494,0.0002467386,0.0003698961,0.0001687324,0.0005411699,0.0001582863,0.0001859919,0.001221587],"category_scores_gemma":[0.001324315,0.00015006,0.0003543603,0.000478815,0.0002540764,0.000192328,0.0001369423,0.0002756295,0.0001407648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002821556,"about_ca_system_score_gemma":0.0002209861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005188745,"about_ca_topic_score_gemma":0.003032185,"domain_scores_codex":[0.9996141,0.0001890618,0.00002873175,0.00006595164,0.00006964103,0.00003267158],"domain_scores_gemma":[0.9996401,0.0001121863,0.0001248379,0.00004172066,0.00003946312,0.00004165768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0297295,0.00023518,0.422277,0.0002144844,0.001958665,0.00184175,0.0006822447,0.002694542,0.4891756,0.0017882,0.0006135341,0.04878934],"study_design_scores_gemma":[0.0003253962,0.001975857,0.8005198,0.00002701742,0.001080499,0.003748341,0.0002629408,0.006845797,0.1790489,0.001070746,0.005049742,0.00004494716],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99779,0.001209359,0.0003690516,0.0000394785,0.000007782583,0.000003715198,0.0001865196,0.00001147286,0.000382649],"genre_scores_gemma":[0.9991548,0.0001941872,0.0001762783,0.000009359351,0.000003408534,0.00000192568,0.00009701285,0.000009696674,0.000353388],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005188745,"threshold_uncertainty_score":0.01031709,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005348196311952593,"score_gpt":0.2513091185369182,"score_spread":0.2459609222249656,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}