{"id":"W2988248157","doi":"10.1016/j.cub.2019.09.030","title":"Successive Kinesin-5 Microtubule Crosslinking and Sliding Promote Fast, Irreversible Formation of a Stereotyped Bipolar Spindle","year":2019,"lang":"en","type":"article","venue":"Current Biology","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Fonds de recherche du Québec – Nature et technologies; Canadian Institutes of Health Research; Canada Foundation for Innovation; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"Microtubule; Kinesin; Biology; Spindle pole body; Spindle apparatus; Mitosis; Microtubule nucleation; Cell biology; Multipolar spindles; Biophysics; Cell division; Cell; Genetics; Centrosome; Cell cycle","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001588348,0.0002147212,0.0001842524,0.0002380639,0.0001591823,0.0004071289,0.000223122,0.0001699803,0.002439213],"category_scores_gemma":[0.0002465079,0.0002439391,0.0001885578,0.0001201557,0.0001398838,0.0002204262,0.0003727882,0.0004229463,0.0004962682],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000421544,"about_ca_system_score_gemma":0.0002470771,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000744452,"about_ca_topic_score_gemma":0.00196516,"domain_scores_codex":[0.9999033,0.000006658545,0.000005924504,0.00001812022,0.00002943,0.00003653246],"domain_scores_gemma":[0.9998069,0.00003786191,0.00004266546,0.00002247917,0.00001570557,0.00007430344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004610291,0.0000390635,0.0002260767,0.00003622723,0.000008827605,0.00006476204,0.00002127703,0.0001961122,0.9958287,0.0004322638,0.000227364,0.002458302],"study_design_scores_gemma":[0.00006948164,0.0002185763,0.008663648,0.000007658884,0.00001154274,0.00009481504,0.0000356994,0.003016909,0.9861049,0.0001413958,0.001625743,0.000009634843],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936578,0.0006745829,0.002685201,0.00005465406,0.00005879125,0.00002875143,0.0001251992,0.00018902,0.002526069],"genre_scores_gemma":[0.9974359,0.0001790123,0.0005105154,0.00003236014,0.00001087568,0.00001311381,0.0001184556,0.00002524453,0.001674642],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002439213,"threshold_uncertainty_score":0.008159935,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01139393807753446,"score_gpt":0.2670569019573331,"score_spread":0.2556629638797986,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}