{"id":"W2988277843","doi":"10.1182/blood-2019-124349","title":"Pomalidomide + Bortezomib + Low-Dose Dexamethasone after 1 Prior Line of Therapy in Patients with Lenalidomide-Pretreated Multiple Myeloma: Subanalysis of the Phase 3 Optimismm Trial By Patient Age and Prior Stem Cell Transplant","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Fleurimont; Queen Elizabeth II Health Sciences Centre; Dalhousie University","funders":"","keywords":"Lenalidomide; Medicine; Pomalidomide; Bortezomib; Population; Dexamethasone; Internal medicine; Clinical endpoint; Multiple myeloma; Phases of clinical research; Surgery; Gastroenterology; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002310222,0.000928246,0.002168385,0.0003868234,0.0003902021,0.001066983,0.0006514973,0.0007746532,0.002473303],"category_scores_gemma":[0.00118627,0.0004001141,0.002630774,0.000519672,0.0006927701,0.0006628512,0.0006625914,0.002384036,0.0003586381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001002995,"about_ca_system_score_gemma":0.001634264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007364822,"about_ca_topic_score_gemma":0.002571573,"domain_scores_codex":[0.9991248,0.0005062706,0.00006081557,0.0001224879,0.00005237588,0.0001331246],"domain_scores_gemma":[0.9991882,0.0001709801,0.0002073146,0.0000778541,0.00003299909,0.0003226886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.9447465,0.01014544,0.008169072,0.0004038943,0.002187594,0.00006572788,0.00008602654,0.0008599675,0.004520042,0.00009585665,0.001206285,0.02751369],"study_design_scores_gemma":[0.6396361,0.3283371,0.0238736,0.00006783392,0.002424649,0.0002180202,0.00006495768,0.0009741265,0.00142703,0.0004227742,0.002521692,0.00003220979],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902339,0.005230556,0.0002589737,0.0003903641,0.0001425635,0.001657693,0.0009358907,0.00003081243,0.001119242],"genre_scores_gemma":[0.9931865,0.001760885,0.0006472236,0.0006295734,0.0002250077,0.001758341,0.001128573,0.00001179595,0.0006521381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002473303,"threshold_uncertainty_score":0.01221776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009879637305894647,"score_gpt":0.2385547584379768,"score_spread":0.2286751211320821,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}