{"id":"W2988292717","doi":"10.1038/s41467-019-13150-0","title":"Toll-like receptor 2 expression on c-kit+ cells tracks the emergence of embryonic definitive hematopoietic progenitors","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Zebrafish Biomedical Research Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"European Regional Development Fund; Ministerstvo Zdravotnictví Ceské Republiky; Grantová Agentura České Republiky; Ministerstvo Školství, Mládeže a Tělovýchovy; Univerzita Karlova v Praze","keywords":"Biology; Progenitor cell; Haematopoiesis; Embryonic stem cell; Phenotype; Cell biology; Progenitor; Somatic cell; TLR2; Myeloid; Stem cell; Receptor; Genetics; Immunology; Innate immune system; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002891794,0.0001331567,0.0001307251,0.00005014541,0.0001921468,0.00001469753,0.001641111,0.0003257275,0.0001330578],"category_scores_gemma":[0.0002704583,0.00009647765,0.000117841,0.0003046136,0.000321338,0.000005351293,0.0004864541,0.0006841826,0.0001607128],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000152448,"about_ca_system_score_gemma":0.0001506778,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004180297,"about_ca_topic_score_gemma":0.00002532165,"domain_scores_codex":[0.9987348,0.0002130232,0.0002322271,0.0002774834,0.0003224351,0.0002200682],"domain_scores_gemma":[0.996883,0.0002369435,0.0001364023,0.002418627,0.0002252347,0.00009984526],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003668526,0.0002653638,0.0003165,0.00001745754,0.00003651058,8.834056e-8,0.00009108203,0.000004217003,0.9486429,0.002943815,0.04674944,0.0008959562],"study_design_scores_gemma":[0.0002724048,0.0002061996,0.0008209402,0.00005464418,0.00001436559,0.00000248924,0.0004241879,0.00003947306,0.7289611,0.0001630793,0.2688886,0.0001525884],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9473108,0.0108003,0.000337243,0.01384796,0.0006785423,0.002945362,0.0003647086,0.00006345008,0.02365161],"genre_scores_gemma":[0.995216,0.00168094,0.001521367,0.0003838303,0.00005463674,0.000238262,0.0002790281,0.00002126822,0.0006046795],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2221392,"threshold_uncertainty_score":0.3934244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01343956675509565,"score_gpt":0.3073521803990679,"score_spread":0.2939126136439723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}