{"id":"W2988309127","doi":"10.1182/blood-2019-128746","title":"One-Year Efficacy and Safety from a Phase 3 Trial of Ravulizumab in Adult Patients with Paroxysmal Nocturnal Hemoglobinuria Receiving Prior Eculizumab Treatment","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Paroxysmal nocturnal hemoglobinuria; Eculizumab; Medicine; Hemoglobinuria; Clinical trial; Internal medicine; Pediatrics; Anemia; Immunology; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003735253,0.001274818,0.002334385,0.0003320175,0.0008522475,0.00110058,0.0006193444,0.001332792,0.002745632],"category_scores_gemma":[0.002021726,0.0005546472,0.002005503,0.0002677556,0.0007459401,0.001132331,0.0004745959,0.003411892,0.0006566684],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007216195,"about_ca_system_score_gemma":0.001289619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007271781,"about_ca_topic_score_gemma":0.001309151,"domain_scores_codex":[0.9988794,0.0005031403,0.00008128462,0.00019538,0.00009306156,0.0002477017],"domain_scores_gemma":[0.9985957,0.0002068828,0.0002781357,0.0001432076,0.00008913843,0.0006870046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8504682,0.04932933,0.01346735,0.0003610176,0.001915956,0.0003135042,0.0003092687,0.001368707,0.01749452,0.0001322255,0.003493472,0.06134649],"study_design_scores_gemma":[0.4019902,0.5510219,0.04100025,0.00003729674,0.0008544194,0.0003371512,0.00005760523,0.001145379,0.001563677,0.0001703131,0.00177765,0.00004404892],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944972,0.001625345,0.0003986385,0.0002988901,0.0001056112,0.001338958,0.0006113109,0.00005836736,0.001065709],"genre_scores_gemma":[0.9940664,0.0006097221,0.0005742549,0.0007565569,0.000188267,0.00159084,0.001232839,0.00001178255,0.0009693819],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003735253,"threshold_uncertainty_score":0.01975417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009088850169246068,"score_gpt":0.2372468389300905,"score_spread":0.2281579887608445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}