{"id":"W2988309127","doi":"10.1182/blood-2019-128746","title":"One-Year Efficacy and Safety from a Phase 3 Trial of Ravulizumab in Adult Patients with Paroxysmal Nocturnal Hemoglobinuria Receiving Prior Eculizumab Treatment","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Paroxysmal nocturnal hemoglobinuria; Eculizumab; Medicine; Hemoglobinuria; Clinical trial; Internal medicine; Pediatrics; Anemia; Immunology; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007671805,0.000222936,0.0005358545,0.00008840153,0.00005745736,0.00001344933,0.0001455249,0.0001167571,0.0006855319],"category_scores_gemma":[0.00006471133,0.000181716,0.00007040296,0.00009236549,0.00006933815,0.00007100213,0.00006490226,0.0001066161,0.00006281085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007528144,"about_ca_system_score_gemma":0.0001076827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000328273,"about_ca_topic_score_gemma":0.00012614,"domain_scores_codex":[0.9984837,0.0002378928,0.0005120396,0.0003969834,0.00008201431,0.0002873805],"domain_scores_gemma":[0.9990557,0.0002185126,0.0002593955,0.0003599666,0.00006798562,0.00003840015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.3421145,0.02787306,0.5868528,0.0001414956,0.002140911,0.00001445498,0.002523193,0.000008234529,0.01913791,0.0001071814,0.00007185704,0.01901434],"study_design_scores_gemma":[0.6965963,0.006281334,0.2866779,0.0003507225,0.0003510841,0.000003788214,0.0001651378,0.000001620988,0.008885676,0.00001379595,0.0004151388,0.0002575452],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968939,0.0003546685,0.000002932919,0.00002418742,0.0002476335,0.00184503,0.0003814236,0.00002704645,0.0002231273],"genre_scores_gemma":[0.9993207,0.00002795719,0.0001373466,0.00001025195,0.00003501225,0.00004230806,0.0003407315,0.00001873501,0.00006699208],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3544818,"threshold_uncertainty_score":0.7506094,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009088850169246068,"score_gpt":0.2372468389300905,"score_spread":0.2281579887608445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}