{"id":"W2988313448","doi":"10.1182/blood-2019-123406","title":"Long-Term Safety and Efficacy of Mitapivat (AG-348), a Pyruvate Kinase Activator, in Patients with Pyruvate Kinase Deficiency: The DRIVE PK Study","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Pyruvate kinase deficiency; Medicine; Pyruvate kinase; Adverse effect; Internal medicine; Anemia; Glucose-6-phosphate dehydrogenase deficiency; Gastroenterology; Pediatrics; Glycolysis; Metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001687152,0.0002414223,0.0004865393,0.0001332733,0.00007762215,0.0000104527,0.0001251374,0.00009182289,0.00009283136],"category_scores_gemma":[0.00008216788,0.0001480444,0.00006108586,0.0003678114,0.0001537606,0.00008459712,0.0001015988,0.000287729,0.00002962607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002970241,"about_ca_system_score_gemma":0.00008260635,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005485492,"about_ca_topic_score_gemma":0.00004141241,"domain_scores_codex":[0.9984589,0.0001337098,0.0003594748,0.0004431978,0.0003003356,0.0003044257],"domain_scores_gemma":[0.9988318,0.0001786846,0.0001861136,0.0005774024,0.0001202338,0.0001057397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003118679,0.00504525,0.9770894,0.00009102378,0.0001096399,0.00004427979,0.001602615,0.00000833535,0.01193742,0.00003602739,0.00001073982,0.0009065597],"study_design_scores_gemma":[0.02501709,0.004122493,0.9666077,0.000156765,0.0001997826,0.000003893041,0.0004387087,0.000005934431,0.00322471,0.000006637654,0.00005124773,0.0001650687],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997551,0.0001460993,0.000004250278,0.0001060133,0.0001357592,0.001652652,0.00001443861,0.00003266514,0.0003570697],"genre_scores_gemma":[0.9994357,0.0000339441,0.00003170979,0.000236666,0.00003278563,0.00001916567,0.00003231833,0.00002888056,0.0001488635],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02189841,"threshold_uncertainty_score":0.6037074,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00802904632412506,"score_gpt":0.2297125436749147,"score_spread":0.2216834973507896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}