{"id":"W2988313448","doi":"10.1182/blood-2019-123406","title":"Long-Term Safety and Efficacy of Mitapivat (AG-348), a Pyruvate Kinase Activator, in Patients with Pyruvate Kinase Deficiency: The DRIVE PK Study","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Pyruvate kinase deficiency; Medicine; Pyruvate kinase; Adverse effect; Internal medicine; Anemia; Glucose-6-phosphate dehydrogenase deficiency; Gastroenterology; Pediatrics; Glycolysis; Metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001790595,0.0006917795,0.001707075,0.0002347955,0.0003663373,0.0008684645,0.0004800441,0.0009824062,0.002788705],"category_scores_gemma":[0.001823711,0.0003673055,0.001378573,0.0002516734,0.0005079507,0.0008668289,0.0004050439,0.001850457,0.0006109113],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000622221,"about_ca_system_score_gemma":0.000580726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002057675,"about_ca_topic_score_gemma":0.000660676,"domain_scores_codex":[0.9993561,0.0003030556,0.00006583479,0.0001294371,0.00007720612,0.00006830534],"domain_scores_gemma":[0.9986047,0.0003239795,0.0004919182,0.0001252285,0.0001020777,0.0003521832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8309985,0.01497156,0.0338516,0.001268405,0.004290446,0.0002542248,0.0002186343,0.001085576,0.01051428,0.0002273987,0.00375443,0.09856486],"study_design_scores_gemma":[0.4866751,0.4278434,0.0725521,0.0001619851,0.003235751,0.000769716,0.0001246319,0.001346637,0.002154589,0.0003736333,0.004698384,0.00006417833],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903181,0.005921421,0.0002610255,0.0003179594,0.00007897272,0.0005927633,0.001072837,0.00003069342,0.001406222],"genre_scores_gemma":[0.9945425,0.001504395,0.000375005,0.0005728361,0.000165794,0.0007305897,0.001266282,0.000006834805,0.000835721],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002788705,"threshold_uncertainty_score":0.009469688,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00802904632412506,"score_gpt":0.2297125436749147,"score_spread":0.2216834973507896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}