{"id":"W2988318627","doi":"10.4049/immunohorizons.1900087","title":"Galectin-9 Expression Defines a Subpopulation of NK Cells with Impaired Cytotoxic Effector Molecules but Enhanced IFN-γ Production, Dichotomous to TIGIT, in HIV-1 Infection","year":2019,"lang":"en","type":"article","venue":"ImmunoHorizons","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"TIGIT; Cytotoxic T cell; Perforin; Degranulation; Interleukin 21; Granzyme; Granzyme B; Biology; Interleukin 12; Granulysin; Effector; Immunology; Janus kinase 3; Lymphokine-activated killer cell; NK-92; Cell biology; CD8; Immune system; Receptor; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002180639,0.0002853198,0.0004031317,0.0004781392,0.000129173,0.00002264044,0.000125868,0.0002308073,0.0004568771],"category_scores_gemma":[0.0001257562,0.0002481508,0.0001080545,0.0005530327,0.00006347618,0.0003114353,0.00005190012,0.0003422986,0.001148878],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001594277,"about_ca_system_score_gemma":0.00006521022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008503593,"about_ca_topic_score_gemma":0.00016495,"domain_scores_codex":[0.998286,0.0002754191,0.0005161954,0.0004838805,0.00008488616,0.0003535988],"domain_scores_gemma":[0.9989095,0.00009404807,0.000286633,0.000480362,0.0002044644,0.00002503172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001689213,0.0002785373,0.01357129,0.00007085053,0.00006215852,8.466005e-7,0.0004480592,0.0006880662,0.9813324,0.00001058918,0.001168068,0.0006799208],"study_design_scores_gemma":[0.0013405,0.001178469,0.06175148,0.0003306866,0.00002861612,0.00004044185,0.0001400411,0.00001178182,0.9331281,0.000006967516,0.001779088,0.0002637896],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992451,0.0002407257,0.001502017,0.00005319003,0.003771034,0.001275202,0.000007830576,0.0001334182,0.0005655474],"genre_scores_gemma":[0.9924275,0.00004677135,0.000125417,0.00002553993,0.00003898087,0.000174773,0.0001843253,0.00004007478,0.006936633],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04820426,"threshold_uncertainty_score":0.9999971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005749943550426313,"score_gpt":0.2176742400706697,"score_spread":0.2119242965202434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}