{"id":"W2988318627","doi":"10.4049/immunohorizons.1900087","title":"Galectin-9 Expression Defines a Subpopulation of NK Cells with Impaired Cytotoxic Effector Molecules but Enhanced IFN-γ Production, Dichotomous to TIGIT, in HIV-1 Infection","year":2019,"lang":"en","type":"article","venue":"ImmunoHorizons","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"TIGIT; Cytotoxic T cell; Perforin; Degranulation; Interleukin 21; Granzyme; Granzyme B; Biology; Interleukin 12; Granulysin; Effector; Immunology; Janus kinase 3; Lymphokine-activated killer cell; NK-92; Cell biology; CD8; Immune system; Receptor; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009042376,0.0002309423,0.0001879646,0.0002793241,0.0001258336,0.0003959344,0.0001019321,0.0002269172,0.001022388],"category_scores_gemma":[0.0001419028,0.0001418266,0.0001590292,0.0001521621,0.0002097155,0.0001591043,0.0002808931,0.0003329844,0.0001344364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001129904,"about_ca_system_score_gemma":0.0000376363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001872794,"about_ca_topic_score_gemma":0.0001411011,"domain_scores_codex":[0.9999075,0.0000160407,0.00001135802,0.00002608093,0.00001468536,0.0000243948],"domain_scores_gemma":[0.9999359,0.000008165203,0.00002045322,0.000008229667,0.000006226652,0.00002108847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005726252,0.00004962111,0.01893044,0.00003262634,0.00001784907,0.0002675611,0.000107029,0.0000458771,0.9773909,0.00003842402,0.00001976406,0.002527261],"study_design_scores_gemma":[0.00008033259,0.001787937,0.7549602,0.0000263631,0.0001286714,0.007529921,0.0005293105,0.002023598,0.2310409,0.0002780858,0.001590289,0.00002448335],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994534,0.0001701472,0.0001556163,0.000004310958,0.000001433409,0.000006360947,0.00004477613,0.000004460077,0.0001595284],"genre_scores_gemma":[0.9993953,0.00008218196,0.0001775229,0.000008587184,0.000003330754,0.000008000701,0.0001103275,0.000002239451,0.0002125473],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001022388,"threshold_uncertainty_score":0.003420293,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005749943550426313,"score_gpt":0.2176742400706697,"score_spread":0.2119242965202434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}