{"id":"W2988337261","doi":"10.2174/0929866526666191026111951","title":"Physiological State Dictates the Proteasomal-Mediated Purging of Misfolded Protein Fragments","year":2019,"lang":"en","type":"article","venue":"Protein and Peptide Letters","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Cell biology; Protein folding; Biology; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000268137,0.0003064735,0.0002873791,0.0001790172,0.0002029527,0.0007572728,0.0002056328,0.0004239272,0.0007105467],"category_scores_gemma":[0.000168624,0.0001260148,0.0001684573,0.0001577049,0.0006645109,0.0004055235,0.0002503772,0.0003336122,0.0002958042],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004414345,"about_ca_system_score_gemma":0.0002994878,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002625105,"about_ca_topic_score_gemma":0.0003668603,"domain_scores_codex":[0.9998298,0.00003454172,0.00001910459,0.00005132399,0.00002993508,0.00003530051],"domain_scores_gemma":[0.9999065,0.00002509174,0.00002843505,0.000008156255,0.000009277723,0.00002237218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003127484,0.00005006485,0.001735723,0.0001792982,0.000007336587,0.0006209717,0.000029756,0.0002518207,0.9898267,0.002022004,0.0002169825,0.004746736],"study_design_scores_gemma":[0.00002465913,0.0005293252,0.04498378,0.00004086726,0.00002513592,0.001242933,0.0002386863,0.002996651,0.9354005,0.003737461,0.01073722,0.00004276314],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9394084,0.0377178,0.01322581,0.002086217,0.0004104259,0.00007081529,0.0005456111,0.0002514191,0.006283514],"genre_scores_gemma":[0.9875711,0.008343767,0.001980012,0.0002137996,0.00006904976,0.00002052914,0.0001156113,0.00001036593,0.001675568],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007572728,"threshold_uncertainty_score":0.003202856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008506671175960443,"score_gpt":0.2091155038208938,"score_spread":0.2006088326449334,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}