{"id":"W2988337261","doi":"10.2174/0929866526666191026111951","title":"Physiological State Dictates the Proteasomal-Mediated Purging of Misfolded Protein Fragments","year":2019,"lang":"en","type":"article","venue":"Protein and Peptide Letters","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Cell biology; Protein folding; Biology; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003010013,0.0002301471,0.0002245101,0.00003500406,0.00009279924,0.00002767931,0.0002523866,0.00009908976,0.00006669181],"category_scores_gemma":[0.00008299632,0.0001562706,0.00009452255,0.00009245906,0.0001851509,0.000008967677,0.0001664358,0.0001935428,0.00003254719],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007560888,"about_ca_system_score_gemma":0.00002840764,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004228473,"about_ca_topic_score_gemma":0.000002799548,"domain_scores_codex":[0.9985775,0.0001841334,0.0002736802,0.000405836,0.0002027108,0.0003561055],"domain_scores_gemma":[0.9993232,0.00001915705,0.0001793157,0.0003522975,0.00004412424,0.00008187872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001458437,0.00003740293,0.002227049,0.0001274842,0.00005274845,0.000002999988,0.0001218563,0.00001321108,0.9959897,0.00002644635,0.0003011498,0.0009540713],"study_design_scores_gemma":[0.0008879956,0.0004019353,0.004574856,0.0001401505,0.000007976605,0.000005581472,0.00006058461,0.00008109117,0.9863279,0.0002062452,0.007036352,0.000269259],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952598,0.0003698879,0.0001008066,0.001465793,0.00003375264,0.002473068,0.00005463734,0.00002395487,0.0002183096],"genre_scores_gemma":[0.9970484,0.00002998438,0.0006283776,0.001014034,0.00008389981,0.0004166433,0.00006464179,0.00002579752,0.0006881817],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009661764,"threshold_uncertainty_score":0.6372528,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008506671175960443,"score_gpt":0.2091155038208938,"score_spread":0.2006088326449334,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}