{"id":"W2988353924","doi":"10.1158/0008-5472.can-19-1108","title":"CD44 Promotes PD-L1 Expression and Its Tumor-Intrinsic Function in Breast and Lung Cancers","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":162,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University; McGill University Health Centre","funders":"Government of Canada; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Cancer Research Society","keywords":"CD44; Cancer research; Triple-negative breast cancer; Carcinogenesis; Regulator; Lung cancer; Biology; Small hairpin RNA; PD-L1; Breast cancer; Cancer; Downregulation and upregulation; Gene knockdown; Immune system; Medicine; Immunology; Cell; Oncology; Immunotherapy; Internal medicine; Cell culture; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005987479,0.0001198618,0.0002149552,0.0002590821,0.00008755212,0.00003928745,0.00006310218,0.00007559264,0.0006041661],"category_scores_gemma":[0.00002366306,0.00009715409,0.00002620814,0.0004219262,0.0001133363,0.0001516145,0.00007586452,0.0003861282,0.00001101451],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005232942,"about_ca_system_score_gemma":0.00039811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001734601,"about_ca_topic_score_gemma":0.0002247348,"domain_scores_codex":[0.9985614,0.00009306455,0.0001679945,0.0003907914,0.0003972872,0.0003894943],"domain_scores_gemma":[0.9994395,0.00006978145,0.00003494438,0.0001899858,0.0001352893,0.0001305302],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.007942745,0.00004107101,0.120508,0.0006732694,0.0000532568,0.00002560194,0.0005358807,0.000002054678,0.837178,0.00002932453,0.001978899,0.03103192],"study_design_scores_gemma":[0.01130156,0.0009756063,0.8519269,0.003643081,0.00003941765,0.000198149,0.001193963,0.0006671189,0.1192262,0.00009265164,0.01032877,0.0004065325],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9806082,0.01634092,0.000001110414,0.001287117,0.0001739345,0.0008929442,0.0000144271,0.00002148039,0.0006598242],"genre_scores_gemma":[0.9953586,0.002710694,0.000008126157,0.0001727713,0.0001482588,0.0001422091,0.000005836425,0.0000229564,0.001430546],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7314189,"threshold_uncertainty_score":0.6615195,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03377576828142569,"score_gpt":0.3536772769588717,"score_spread":0.319901508677446,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}