{"id":"W2988404632","doi":"10.7554/elife.29595.018","title":"Author response: Clearance of beta-amyloid is facilitated by apolipoprotein E and circulating high-density lipoproteins in bioengineered human vessels","year":2017,"lang":"en","type":"peer-review","venue":"","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Cerebral amyloid angiopathy; Apolipoprotein E; Amyloid (mycology); Amyloid beta; Dementia; Clearance; Disease; Lipoprotein; Biochemistry of Alzheimer's disease; Pathology; Medicine; Neuroscience; Alzheimer's disease; Biology; Amyloid precursor protein; Internal medicine; Cholesterol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002825169,0.001211773,0.0009514473,0.0009199038,0.001557682,0.003514635,0.001654041,0.01474725,0.1265857],"category_scores_gemma":[0.01604711,0.0005067654,0.001246492,0.0003923177,0.001417787,0.001904428,0.002051684,0.00876485,0.05010673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001740513,"about_ca_system_score_gemma":0.002741557,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001660548,"about_ca_topic_score_gemma":0.002537715,"domain_scores_codex":[0.9975903,0.0005757699,0.0001884596,0.0003395815,0.0009424497,0.0003633881],"domain_scores_gemma":[0.9925599,0.002011815,0.0004425089,0.0002486316,0.003637453,0.001099686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002781554,0.000038873,0.000200021,0.0002963871,0.00001621109,0.0001396745,0.00006183853,0.000050725,0.0004774565,0.0004062335,0.9901081,0.007926221],"study_design_scores_gemma":[0.0002232549,0.0001742014,0.00104788,0.0003698632,0.00003078546,0.0001794494,0.0006251709,0.0001512302,0.001046903,0.001068314,0.9950303,0.00005259787],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"other","genre_scores_codex":[0.001960693,0.004632069,0.0008869758,0.6230994,0.3435366,0.0003265855,0.001433177,0.001063134,0.0230614],"genre_scores_gemma":[0.0162723,0.008027782,0.001245505,0.6531977,0.1005022,0.0005591959,0.001565306,0.000480122,0.2181499],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.1265857,"threshold_uncertainty_score":0.4234715,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06691253902994113,"score_gpt":0.3754995031006403,"score_spread":0.3085869640706992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}