{"id":"W2988446212","doi":"10.2174/1871527318666191114092007","title":"Structurally Related Edaravone Analogues: Synthesis, Antiradical, Antioxidant, and Copper-Chelating Properties","year":2019,"lang":"en","type":"article","venue":"CNS & Neurological Disorders - Drug Targets","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; Université de Moncton","funders":"New Brunswick Innovation Foundation; Canada Foundation for Innovation; Fondation Brain Canada; ALS Society of Canada","keywords":"Edaravone; Chemistry; Chelation; Antioxidant; Moiety; Electronegativity; Copper; Combinatorial chemistry; Organic chemistry; Pharmacology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002056873,0.0005597141,0.0003129728,0.0003794381,0.0001543438,0.0002465751,0.000422347,0.000335899,0.001957563],"category_scores_gemma":[0.0002520959,0.0001421667,0.0004355612,0.0003764387,0.0002365978,0.0003993918,0.0002335853,0.0005519762,0.0005839961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002622333,"about_ca_system_score_gemma":0.0003404642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000357521,"about_ca_topic_score_gemma":0.0006704381,"domain_scores_codex":[0.9999121,0.00001555772,0.00001092457,0.00001990906,0.00001626911,0.00002519431],"domain_scores_gemma":[0.9998789,0.00001857199,0.00003159687,0.00001733113,0.00003332752,0.00002023376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006813026,0.0003408558,0.0007195687,0.00131501,0.00007706998,0.0009792253,0.0001514476,0.001763523,0.9458712,0.001073734,0.0003496892,0.04667738],"study_design_scores_gemma":[0.0004326294,0.01492287,0.005831848,0.000222327,0.0002942223,0.00339847,0.0001738296,0.0008519753,0.9022798,0.0007908913,0.07074746,0.00005381108],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9139328,0.05847025,0.01392315,0.0003674241,0.0002085171,0.0006563274,0.001693308,0.00008860352,0.01065957],"genre_scores_gemma":[0.9435684,0.02982932,0.0182865,0.0002421321,0.00007661877,0.0002788614,0.001805172,0.00003599906,0.005876969],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001957563,"threshold_uncertainty_score":0.006548703,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0151755689297097,"score_gpt":0.2401695910815678,"score_spread":0.2249940221518581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}