{"id":"W2988504053","doi":"10.1182/blood-2019-123966","title":"Clinical Activity of CC-90009, a Cereblon E3 Ligase Modulator and First-in-Class GSPT1 Degrader, As a Single Agent in Patients with Relapsed or Refractory Acute Myeloid Leukemia (R/R AML): First Results from a Phase I Dose-Finding Study","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Cereblon; Refractory (planetary science); Ubiquitin ligase; Myeloid leukemia; Internal medicine; Leukemia; Cancer research; Oncology; Chemistry; Ubiquitin; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003239668,0.0002700457,0.0004376437,0.0001100122,0.00006184584,0.0000282216,0.0001843914,0.0002700005,0.000009677001],"category_scores_gemma":[0.0003246222,0.0002214772,0.00007801073,0.0001983691,0.00007364251,0.00002741777,0.0001521969,0.0002697514,0.000005577113],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007291482,"about_ca_system_score_gemma":0.0001764272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004294956,"about_ca_topic_score_gemma":0.001092558,"domain_scores_codex":[0.9978611,0.0001699593,0.000636134,0.0007680171,0.000280442,0.0002842796],"domain_scores_gemma":[0.9987147,0.00009850948,0.0003886039,0.0005897149,0.00006325425,0.0001452534],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03824236,0.09059665,0.6920609,0.000124908,0.0009384832,0.0001693742,0.001857685,0.00002818311,0.1648233,0.00000245704,0.0003703499,0.01078532],"study_design_scores_gemma":[0.2382533,0.01904192,0.3793043,0.0004072653,0.0002227214,0.000005505532,0.0002793136,0.0001916214,0.3595949,0.000007633813,0.001947945,0.0007435651],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99835,0.00008059725,0.000004550855,0.00005275648,0.0001132814,0.001158583,0.0001556341,0.00001391898,0.0000707342],"genre_scores_gemma":[0.999203,0.00007858196,0.0002287578,0.00004925454,0.00006565417,0.00003788035,0.000164873,0.00003349769,0.0001385133],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3127566,"threshold_uncertainty_score":0.903158,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01867240206163048,"score_gpt":0.2764418979414694,"score_spread":0.2577694958798389,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}