{"id":"W2988504053","doi":"10.1182/blood-2019-123966","title":"Clinical Activity of CC-90009, a Cereblon E3 Ligase Modulator and First-in-Class GSPT1 Degrader, As a Single Agent in Patients with Relapsed or Refractory Acute Myeloid Leukemia (R/R AML): First Results from a Phase I Dose-Finding Study","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Cereblon; Refractory (planetary science); Ubiquitin ligase; Myeloid leukemia; Internal medicine; Leukemia; Cancer research; Oncology; Chemistry; Ubiquitin; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005328244,0.0005732327,0.00122013,0.0002931014,0.0001945384,0.0006559413,0.0004483312,0.0004946051,0.001550606],"category_scores_gemma":[0.0005529362,0.0002267758,0.0006500252,0.0003150835,0.0004787077,0.0004510814,0.0001854122,0.001928614,0.0004902999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007534465,"about_ca_system_score_gemma":0.0006288215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000546099,"about_ca_topic_score_gemma":0.002018139,"domain_scores_codex":[0.9997934,0.00006616169,0.00001870682,0.00004257895,0.00004560424,0.00003350827],"domain_scores_gemma":[0.9996138,0.00004909848,0.0000847512,0.0000279174,0.00003403396,0.0001904432],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2241276,0.03468161,0.02217209,0.00178943,0.002463552,0.0007730263,0.0005908565,0.006004105,0.2418671,0.0007467275,0.009879142,0.4549047],"study_design_scores_gemma":[0.2091322,0.6510574,0.07042533,0.0001364405,0.001869142,0.003361987,0.0001911629,0.004617342,0.03768806,0.000575583,0.02082638,0.000118957],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909112,0.005234086,0.0005636828,0.0003312649,0.00004881853,0.0005460393,0.0006306415,0.0001087408,0.001625514],"genre_scores_gemma":[0.9937567,0.002773335,0.0009221953,0.0003963713,0.00006178794,0.0002362904,0.001105437,0.00002118168,0.0007266558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001550606,"threshold_uncertainty_score":0.00546664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01867240206163048,"score_gpt":0.2764418979414694,"score_spread":0.2577694958798389,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}