{"id":"W2988532979","doi":"10.1016/s0140-6736(19)32534-6","title":"Efficacy and safety of upadacitinib in patients with active ankylosing spondylitis (SELECT-AXIS 1): a multicentre, randomised, double-blind, placebo-controlled, phase 2/3 trial","year":2019,"lang":"en","type":"article","venue":"The Lancet","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":346,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"AbbVie","keywords":"Medicine; Ankylosing spondylitis; Placebo; Contraindication; Internal medicine; Clinical endpoint; Spondylitis; Adverse effect; Clinical trial; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001624684,0.00195769,0.003532652,0.0003693681,0.0004900229,0.001210912,0.000758167,0.002297253,0.005456606],"category_scores_gemma":[0.001823049,0.0006135815,0.002348908,0.0004492062,0.0011923,0.001227302,0.0004087431,0.003312133,0.0008673795],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007269169,"about_ca_system_score_gemma":0.0007717196,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009836663,"about_ca_topic_score_gemma":0.00240047,"domain_scores_codex":[0.9994407,0.0002685384,0.0000354289,0.0001009576,0.00004370945,0.0001105905],"domain_scores_gemma":[0.9991515,0.0002746617,0.0002139573,0.0000588702,0.00006330698,0.0002377434],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9857275,0.001299894,0.0005732272,0.0008183376,0.00112395,0.00003790407,0.00003865523,0.0001776834,0.001088742,0.00006856841,0.0007830373,0.00826251],"study_design_scores_gemma":[0.9717385,0.02489658,0.001754431,0.00004433085,0.000713668,0.00004540593,0.00002149219,0.0001602928,0.0001737311,0.0000776326,0.0003614601,0.00001250519],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9799352,0.01357705,0.000385488,0.0008637161,0.0006533564,0.00148878,0.001259466,0.00009604628,0.001740962],"genre_scores_gemma":[0.9895135,0.004251872,0.0005657508,0.001032751,0.0004050131,0.001275311,0.001217748,0.00001714906,0.001720889],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005456606,"threshold_uncertainty_score":0.01825416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02036701321114847,"score_gpt":0.2936626607836592,"score_spread":0.2732956475725107,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}