{"id":"W2988547350","doi":"10.1074/jbc.ra119.010302","title":"Gcn5 and Esa1 function as histone crotonyltransferases to regulate crotonylation-dependent transcription","year":2019,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Government of Canada","keywords":"Histone Acetyltransferases; Histone acetyltransferase; Histone; Biology; Cell biology; Succinylation; P300-CBP Transcription Factors; Histone H3; Acetylation; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002164521,0.0001441582,0.0001993809,0.00002178899,0.00004442746,0.00002833085,0.0001306816,0.0002458451,0.0002159167],"category_scores_gemma":[0.00004642733,0.0001151078,0.0001144004,0.00004375064,0.00004416123,0.000006075978,0.00003171974,0.0001448679,0.00001129536],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003133667,"about_ca_system_score_gemma":0.00004459634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000314299,"about_ca_topic_score_gemma":8.770534e-7,"domain_scores_codex":[0.9991239,0.00002611782,0.0003486373,0.0002238879,0.0001248611,0.0001526283],"domain_scores_gemma":[0.9994422,0.00001226454,0.0001407378,0.0001522927,0.0001169826,0.0001354943],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004384055,0.00005755453,0.002598306,0.00003177596,0.00003947016,0.000003574758,0.0000217059,0.0002189183,0.995667,0.00001566442,0.0001053364,0.0008022664],"study_design_scores_gemma":[0.001043642,0.001427251,0.01230008,0.00003786848,0.00003356534,0.0003260063,0.0001234747,0.0000550799,0.9728673,0.0004345211,0.01109503,0.0002561434],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971654,0.0005493346,0.0010744,0.0001840227,0.0001367898,0.0001689069,0.00001116035,0.000005363838,0.0007046483],"genre_scores_gemma":[0.9980221,0.000283194,0.0004104312,0.0002231495,0.0001832148,0.000005387377,0.00003344761,0.00001103959,0.000827968],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02279969,"threshold_uncertainty_score":0.4693962,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007722029725566734,"score_gpt":0.2315679636896999,"score_spread":0.2238459339641331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}