{"id":"W2988632400","doi":"10.1097/ccm.0000000000004095","title":"Suppression of Superoxide-Hydrogen Peroxide Production at Site IQ of Mitochondrial Complex I Attenuates Myocardial Stunning and Improves Postcardiac Arrest Outcomes","year":2019,"lang":"en","type":"article","venue":"Critical Care Medicine","topic":"Cardiac Arrest and Resuscitation","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Canadian Institutes of Health Research; National Institutes of Health; National Heart, Lung, and Blood Institute; Mallinckrodt Pharmaceuticals","keywords":"Medicine; Resuscitation; Cardiopulmonary resuscitation; Myocardial stunning; Anesthesia; Mitochondrial permeability transition pore; Cardiogenic shock; Superoxide; Internal medicine; Cardiology; Ischemia; Myocardial infarction; Apoptosis; Programmed cell death; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002680148,0.0004425702,0.0005019258,0.0001798626,0.0001021866,0.0002644743,0.0002859263,0.0002327086,0.001111343],"category_scores_gemma":[0.0002110796,0.000100369,0.000193726,0.00009589068,0.0002653009,0.0002575073,0.0001282768,0.0006879098,0.0001816009],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001347865,"about_ca_system_score_gemma":0.0002581728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001977182,"about_ca_topic_score_gemma":0.000350663,"domain_scores_codex":[0.9998796,0.00002000457,0.00001368017,0.00002563009,0.00002367694,0.00003730433],"domain_scores_gemma":[0.9997,0.0000187664,0.0001442067,0.00002217701,0.00002760556,0.00008723894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005501182,0.001228375,0.001115561,0.0001319459,0.00003937674,0.00003939872,0.00002703456,0.0001193559,0.9853436,0.00007727355,0.0001187677,0.006258185],"study_design_scores_gemma":[0.001855384,0.06850109,0.03323155,0.00008827345,0.0002541591,0.0003984342,0.0001390764,0.001632607,0.8922752,0.0001187096,0.001486766,0.00001883845],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980547,0.0005814235,0.000879082,0.00005492382,0.00002600548,0.00004388026,0.00008808162,0.00004105151,0.0002307794],"genre_scores_gemma":[0.9977276,0.0005820727,0.0007872155,0.00004820822,0.0000202125,0.00006062041,0.0001934495,0.000007995429,0.0005726339],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001111343,"threshold_uncertainty_score":0.00371778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01503589440682043,"score_gpt":0.3000098982818687,"score_spread":0.2849740038750483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}