{"id":"W2988699852","doi":"10.2217/pgs-2019-0091","title":"Combination of Germline Variations Associated with Survival of Folinic Acid, Fluorouracil and Irinotecan-Treated Metastatic Colorectal Cancer Patients","year":2019,"lang":"en","type":"article","venue":"Pharmacogenomics","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa; Université Laval; Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research","keywords":"Irinotecan; Colorectal cancer; Folinic acid; Medicine; Internal medicine; Oncology; Hazard ratio; Single-nucleotide polymorphism; Fluorouracil; Cancer; FOLFIRI; Biology; Gene; Genotype; Genetics; Confidence interval","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002370763,0.0001994391,0.0002238469,0.0002674257,0.0002032261,0.0002689622,0.000129392,0.0002712076,0.002040573],"category_scores_gemma":[0.0008184006,0.0000829483,0.0003318973,0.0004782973,0.0001407343,0.00009546871,0.00016035,0.0002181482,0.000115878],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001682945,"about_ca_system_score_gemma":0.0001458068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001764895,"about_ca_topic_score_gemma":0.003178495,"domain_scores_codex":[0.9997858,0.00004465062,0.0000221025,0.00008055245,0.00003368311,0.00003321176],"domain_scores_gemma":[0.9996062,0.0001116336,0.0001728321,0.00004146499,0.00002070506,0.0000471967],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0012681,0.00003476025,0.984529,0.00002328298,0.0003987304,0.0002491774,0.0000457535,0.000267036,0.008275736,0.00004445939,0.000132878,0.004731161],"study_design_scores_gemma":[0.00002006766,0.0001869663,0.997386,0.000005886628,0.0002071531,0.0005082674,0.00002996295,0.0004714342,0.0008531219,0.00006375299,0.0002635484,0.000003763624],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992065,0.0002369579,0.00008983903,0.00002400269,0.00000321183,0.000001607336,0.0003096172,0.000002856642,0.0001254661],"genre_scores_gemma":[0.99967,0.00003054199,0.00004940708,0.00000732566,0.000003463031,0.000001114086,0.0001698675,9.170205e-7,0.00006733943],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002040573,"threshold_uncertainty_score":0.006826341,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02247407148928582,"score_gpt":0.3002783786496603,"score_spread":0.2778043071603745,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}