{"id":"W2988699852","doi":"10.2217/pgs-2019-0091","title":"Combination of Germline Variations Associated with Survival of Folinic Acid, Fluorouracil and Irinotecan-Treated Metastatic Colorectal Cancer Patients","year":2019,"lang":"en","type":"article","venue":"Pharmacogenomics","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa; Université Laval; Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research","keywords":"Irinotecan; Colorectal cancer; Folinic acid; Medicine; Internal medicine; Oncology; Hazard ratio; Single-nucleotide polymorphism; Fluorouracil; Cancer; FOLFIRI; Biology; Gene; Genotype; Genetics; Confidence interval","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001105571,0.0001446706,0.000463928,0.00008004266,0.00004013623,0.000004295984,0.00003843086,0.00003040977,0.00009576198],"category_scores_gemma":[0.0000431933,0.0001144062,0.00005501879,0.0002033921,0.00005990388,0.00005691031,0.00003474099,0.00007456632,0.000001767412],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001771847,"about_ca_system_score_gemma":0.0001145413,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002664416,"about_ca_topic_score_gemma":0.0001623082,"domain_scores_codex":[0.9991269,0.00004567585,0.0003071934,0.0001771561,0.0001991686,0.0001439829],"domain_scores_gemma":[0.9990496,0.0001274573,0.000293378,0.00007191134,0.0004006029,0.00005703235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001966191,0.001708532,0.9462223,0.0001361877,0.00244665,0.000003643111,0.0008458688,0.00005267201,0.04107057,0.000061628,0.00002301949,0.005462753],"study_design_scores_gemma":[0.01495341,0.002863774,0.9185155,0.00009121994,0.00181446,0.000002307992,0.00009141546,0.00222714,0.05918553,0.00003206059,0.00004524452,0.000177946],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978555,0.0004676231,0.00001143234,0.00007122649,0.0001267381,0.0007099689,0.0003870823,0.00001598001,0.0003544248],"genre_scores_gemma":[0.9991882,0.0003617613,0.00008880596,0.00002599635,0.00001107687,0.00003963945,0.0001647004,0.00001909147,0.0001006836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0277068,"threshold_uncertainty_score":0.4665348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02247407148928582,"score_gpt":0.3002783786496603,"score_spread":0.2778043071603745,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}