{"id":"W2988701053","doi":"10.1182/blood-2019-125716","title":"Ibrutinib Therapy Downregulates Toso, the Fcr for IgM, Expression in CLL Patients","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Ibrutinib; breakpoint cluster region; B-cell receptor; Internal medicine; Bruton's tyrosine kinase; B cell; IGHV@; Waldenstrom macroglobulinemia; Rituximab; Chemistry; Cancer research; Immunology; Chronic lymphocytic leukemia; Leukemia; Medicine; Receptor; Lymphoma; Antibody; Tyrosine kinase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001043773,0.0001677676,0.0002500875,0.000395767,0.0001890068,0.0003318694,0.00008200936,0.000178487,0.001078545],"category_scores_gemma":[0.000196484,0.00008465502,0.0001395402,0.00027655,0.000109932,0.00007445995,0.0001169163,0.000191364,0.0001449999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003864165,"about_ca_system_score_gemma":0.0001631889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001294906,"about_ca_topic_score_gemma":0.002002827,"domain_scores_codex":[0.9999025,0.00001213679,0.000006983249,0.00001767437,0.00003006268,0.00003062218],"domain_scores_gemma":[0.9999369,0.00001067782,0.00002306525,0.000003374993,0.00001212212,0.00001388229],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003756299,0.0001686996,0.1187863,0.0001460865,0.00009306514,0.0003285816,0.0002520141,0.0004818554,0.8434191,0.00006687485,0.0008026632,0.03169844],"study_design_scores_gemma":[0.0001485153,0.002052257,0.8328618,0.00003680936,0.0002530972,0.001441297,0.0003621167,0.001243986,0.1535304,0.00007911129,0.007973501,0.00001703019],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980265,0.0009794843,0.0001074935,0.00002566725,0.000004671136,0.000007436005,0.0002646791,0.00002099448,0.0005630456],"genre_scores_gemma":[0.9984976,0.0003327617,0.0001899965,0.00005086138,0.000006710749,0.00002252408,0.0004475023,0.000003970508,0.0004481811],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001294906,"threshold_uncertainty_score":0.003608108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01511424877564102,"score_gpt":0.2822830534277203,"score_spread":0.2671688046520793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}